An antimicrobial peptide
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β-Defensin-3 (human) (trifluoroacetate salt)

Item No. 24578

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • hBD-3
Molecular Formula
C216H371N75O59S6 • XCF3COOH
Formula Weight
5155.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@](C(N1CCC[C@H]1C(N[C@H](C(NC(C(N[C@](C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]2([C@@H](C)O)[H])=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)C)=O)([C@H](CC)C)[H])=O)CSSC[C@@H]4NC5=O)=O)C)=O)=O)([C@H](CC)C)[H])=O)=O)CSSC[C@H](NC2=O)C(N[C@](C(N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H]5CC6=CC=CC=C6)=O)C)=O)CC7=CNC8=C7C=CC=C8)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O)([C@H](CC)C)[H])=O)=O)CC%10=CC=C(O)C=C%10)=O)CSSC[C@H](NC4=O)C(O)=O)=O)CC(O)=O.FC(C(O)=O)(F)F.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C151H222N44O40S6.2C2HF3O2/c1-13-74(6)117-143(230)172-77(9)121(208)167-64-112(201)174-97(48-50-115(204)205)130(217)176-93(31-22-52-163-149(156)157)128(215)175-94(32-23-53-164-150(158)159)129(216)181-99(58-82-35-41-86(197)42-36-82)126(213)169-66-114(203)191-120(80(12)196)145(232)189-108-71-239-236-68-105-137(224)177-95(33-24-54-165-151(160)161)131(218)194-119(76(8)15-3)146(233)195-55-25-34-110(195)142(229)171-79(11)123(210)185-107(140(227)192-117)70-238-237-69-106(139(226)190-109(147(234)235)72-241-240-67-104(186-124(211)90(152)62-116(206)207)138(225)182-101(136(223)187-105)59-83-37-43-87(198)44-38-83)188-135(222)100(57-81-26-17-16-18-27-81)179-122(209)78(10)170-132(219)103(61-85-63-166-91-29-20-19-28-89(85)91)183-133(220)98(56-73(4)5)180-127(214)92(30-21-51-162-148(154)155)173-113(202)65-168-125(212)96(47-49-111(153)200)178-134(221)102(60-84-39-45-88(199)46-40-84)184-144(231)118(75(7)14-2)193-141(108)228;2*3-2(4,5)1(6)7/h16-20,26-29,35-46,63,73-80,90,92-110,117-120,166,196-199H,13-15,21-25,30-34,47-62,64-72,152H2,1-12H3,(H2,153,200)(H,167,208)(H,168,212)(H,169,213)(H,170,219)(H,171,229)(H,172,230)(H,173,202)(H,174,201)(H,175,215)(H,176,217)(H,177,224)(H,178,221)(H,179,209)(H,180,214)(H,181,216)(H,182,225)(H,183,220)(H,184,231)(H,185,210)(H,186,211)(H,187,223)(H,188,222)(H,189,232)(H,190,226)(H,191,203)(H,192,227)(H,193,228)(H,194,218)(H,204,205)(H,206,207)(H,234,235)(H4,154,155,162)(H4,156,157,163)(H4,158,159,164)(H4,160,161,165);2*(H,6,7)/t74-,75-,76-,77-,78-,79-,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107?,108-,109-,110-,117-,118-,119-,120-;;/m0../s1
InChi Key
XZQWIGLJPFMQTF-CJFNZAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l).2 It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans.3 β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes when used at a concentration of 30 μg/ml.4 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 5, and 20 μg/ml, respectively. β-Defensin-3 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehrer, R.I. Primate defensins. Nat. Rev. Microbiol. 2(9), 727-738 (2004).

    2. Ouhara, K., Komatsuzawa, H., Yamada, S., et al. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cells. J. Antimicrob. Chemother. 55(6), 888-896 (2005).

    3. Harder, J., Bartels, J., Christophers, E., et al. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. The Journal of Biological Chemisty 276(8), 5707-5713 (2001).

    4. Niyonsaba, F., Ushio, H., Nakano, N., et al. Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J. Invest. Dermatol. 127(3), 594-604 (2007).

    5. Niyonsaba, F., Ushio, H., Hara, M., et al. Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J. Immunol. 184(7), 3526-3534 (2010).