A hydroxy fatty acid
Related Products
Isomer(s)
2849412-hydroxy Lauric Acid
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2-hydroxy Lauric Acid

Item No. 24586

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-dodecanoic acid
CAS Number
2984-55-6
Synonyms
  • (±)-2-hydroxy Dodecanoic Acid
  • (±)-α-hydroxy Dodecanoic Acid
  • FA 12:0;O
  • (±)-α-hydroxy Lauric Acid
  • NSC 39025
Molecular Formula
C12H24O3
Formula Weight
216.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
CCCCCCCCCCC(O)C(O)=O
InChi Code
InChI=1S/C12H24O3/c1-2-3-4-5-6-7-8-9-10-11(13)12(14)15/h11,13H,2-10H2,1H3,(H,14,15)
InChi Key
YDZIJQXINJLRLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Product Description

    2-hydroxy Lauric acid is a naturally occuring hydroxylated fatty acid that is found in Acinetobacter species.1 It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro (EC50s = 6.7 and 12.8 μM, respectively).2 2-hydroxy Lauric acid also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.3 [Matreya, LLC. Catalog No. 1701]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moss, C.W., Wallace, P.L., Hollis, D.G., et al. Cultural and chemical characterization of CDC groups EO-2, M-5, and M-6, Moraxella (Moraxella) species, Oligella urethralis, Acinetobacter species, and Psychrobacter immobilis. J. Clin. Microbiol. 26(3), 484-492 (1988).

    2. Kaspersen, M.H., Jenkins, L., Dunlop, J., et al. Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4, and GPR84. Med. Chem. Commun. 8(6), 1360-1365 (2017).

    3. Barrientos, L., Marin-Esteban, V., de Chaisemartin, L., et al. An improved strategy to recover large fragments of functional human neutrophil extracellular traps. Front. Immunol. 4(166), 1-10 (2013).