A sphingolipid
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Asialo Ganglioside GM2

Item No. 24629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-O-[O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide
CAS Number
35960-33-9
Synonyms
  • Asialo-GM2
  • Asialoganglioside GM2
  • Gangliotriaosylceramide
Molecular Formula
C56H104N2O18 (for stearoyl)
Formula Weight
1093.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform:Methanol:Water (2:1:0.1): Soluble
SMILES
[R]C(N[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@]2([H])O[C@H](CO)[C@H](O[C@@]3([H])[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@H](O)[C@H]2O)[C@@H](CO)O1)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $842

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    Product Description

    Asialo ganglioside GM2 (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.1 It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients.2 This product contains asialo ganglioside GM2 molecular species with variable fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid. [Matreya, LLC. Catalog No. 1512]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baek, R.C., Martin, D.R., Cox, N.R., et al. Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids 44(3), 197-205 (2009).

    2. Krivan, H.C., Ginsburg, V., and Roberts, D.D. Pseudomonas aeruginosa and Pseudomonas cepacia isolated from cystic fibrosis patients bind specifically to gangliotetraosylceramide (asialo GM1) and gangliotriaosylceramide (asialo GM2). Arch. Biochem. Biophys. 260(1), 493-496 (1988).