A fluorogenic substrate for MMP-1 and MMP-8
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Dnp-PLALWAR (trifluoroacetate salt)

Item No. 24662

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,4-dinitrophenyl)-L-prolyl-L-leucyl-L-alanyl-L-leucyl-L-tryptophyl-L-alanyl-L-arginine, trifluoroacetate salt
Synonyms
  • Matrix Metalloproteinase-1 Fluorogenic Substrate I
  • MMP-1 Fluorogenic Substrate I
Molecular Formula
C46H65N13O12 • XCF3COOH
Formula Weight
992.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(N[C@@H](C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)[C@@H](NC([C@@H](NC([C@H](C)NC([C@H](CC(C)C)NC([C@H]1N(C2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)CCC1)=O)=O)=O)CC(C)C)=O)CC3=CNC4=C3C=CC=C4.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C46H65N13O12.C2HF3O2/c1-24(2)19-33(56-44(65)37-14-10-18-57(37)36-16-15-29(58(68)69)22-38(36)59(70)71)41(62)51-27(6)40(61)54-34(20-25(3)4)43(64)55-35(21-28-23-50-31-12-8-7-11-30(28)31)42(63)52-26(5)39(60)53-32(45(66)67)13-9-17-49-46(47)48;3-2(4,5)1(6)7/h7-8,11-12,15-16,22-27,32-35,37,50H,9-10,13-14,17-21H2,1-6H3,(H,51,62)(H,52,63)(H,53,60)(H,54,61)(H,55,64)(H,56,65)(H,66,67)(H4,47,48,49);(H,6,7)/t26-,27-,32-,33-,34-,35-,37-;/m0./s1
InChi Key
YUJRTFFHQYEQRE-KCTNGUTDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $112

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    1 mg

    $212

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    Product Description

    Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8.1 The activity of MMP-1 and MMP-8 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Netzel-Arnett, S., Mallya, S.K., Nagase, H., et al. Continuously recording fluorescent assays optimized for five human matrix metalloproteinases. Anal. Biochem. 195(1), 86-92 (1991).