A fluorogenic substrate for MMP-1 and MMP-9
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Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2

Item No. 24664

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-N-((7S,10S,13S,16R,19S,22S)-13-((1H-imidazol-5-yl)methyl)-7-carbamoyl-23-cyclohexyl-19-ethyl-10-methyl-1-(2-(methylamino)phenyl)-16-((methylthio)methyl)-1,9,12,15,18,21-hexaoxo-2,8,11,14,17,20-hexaazatricosan-22-yl)-1-(2,4-dinitrophenyl)pyrrolidine-2-carboxamide
Synonyms
  • Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(Nma)-NH2
  • Matrix Metalloproteinase-1 Fluorogenic Substrate III
  • MMP-1 Fluorogenic Substrate III
Molecular Formula
C51H72N14O12S
Formula Weight
1105.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
NC([C@H](CCCCNC(C1=CC=CC=C1NC)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)CC4CCCCC4)=O)CC)=O)CSC)=O)CC5=CN=CN5)=O)C)=O)=O
InChi Code
InChI=1S/C51H72N14O12S/c1-5-35(58-49(71)38(24-31-14-7-6-8-15-31)61-51(73)42-19-13-23-63(42)41-21-20-33(64(74)75)26-43(41)65(76)77)47(69)62-40(28-78-4)50(72)60-39(25-32-27-54-29-56-32)48(70)57-30(2)45(67)59-37(44(52)66)18-11-12-22-55-46(68)34-16-9-10-17-36(34)53-3/h9-10,16-17,20-21,26-27,29-31,35,37-40,42,53H,5-8,11-15,18-19,22-25,28H2,1-4H3,(H2,52,66)(H,54,56)(H,55,68)(H,57,70)(H,58,71)(H,59,67)(H,60,72)(H,61,73)(H,62,69)/t30-,35-,37-,38-,39-,40-,42-/m0/s1
InChi Key
ZXWDGVAWRUKOAR-IHGWQQAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $468

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    Product Description

    Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9.1 Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bickett, D.M., Green, M.D., Berman, J., et al. A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9). Anal. Biochem. 212(1), 58-64 (1993).