An inhibitor of MMP-2 and MMP-9
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MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt)

Item No. 24697

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophylglycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine, cyclic (1→10)-disulfide, 2,2,2-trifluoroacetate
Synonyms
  • Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III
Molecular Formula
C52H71N13O14S2 • XCF3COOH
Formula Weight
1166.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC(C)C)C2=O)=O)=O)CNC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CC5=CNC=N5)NC([C@@]([C@H](O)C)([H])NC([C@@]([C@H](O)C)([H])NC([C@@H](N)CSSC[C@@H](C(O)=O)N2)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C52H71N13O14S2.C2HF3O2/c1-25(2)15-35-46(72)62-39(52(78)79)23-81-80-22-33(53)44(70)63-43(28(5)68)51(77)65-42(27(4)67)50(76)61-38(18-31-20-54-24-57-31)47(73)59-37(17-30-19-55-34-14-10-9-13-32(30)34)45(71)56-21-40(69)58-36(16-29-11-7-6-8-12-29)48(74)64-41(26(3)66)49(75)60-35;3-2(4,5)1(6)7/h6-14,19-20,24-28,33,35-39,41-43,55,66-68H,15-18,21-23,53H2,1-5H3,(H,54,57)(H,56,71)(H,58,69)(H,59,73)(H,60,75)(H,61,76)(H,62,72)(H,63,70)(H,64,74)(H,65,77)(H,78,79);(H,6,7)/t26-,27-,28-,33+,35+,36+,37+,38+,39+,41+,42+,43+;/m1./s1
InChi Key
PXPYGRPAJWZFSK-RWTIKVRNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $236

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    Product Description

    MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 10-20 μM for both).1 It is selective for MMP-2 and MMP-9 over MT1-MMP, MMP-8, and MMP-13 as well as the serine proteases trypsin-2, neutrophil elastase, and cathepsin G when used at a concentration of 500 μM. MMP-2/MMP-9 inhibitor III reduces migration of HT1080 fibrosarcoma, C8161 melanoma, SKOV3 ovarian carcinoma, and KS1767 Kaposi's sarcoma cells in vitro. Pretreatment with MMP-2/MMP-9 inhibitor III delays tumor formation in an MDA-MB-435 mouse xenograft model. MMP-2/MMP-9 inhibitor III (100-200 μg per animal) also prevents growth of established tumors in MDA-MB-435 and KS1767 mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koivunen, E., Arap, W., Valtanen, H., et al. Tumor targeting with a selective gelatinase inhibitor. Nat. Biotechnol. 17(8), 768-774 (1999).