A fluorogenic substrate for MMP-8 and MMP-26
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Dnp-PLAYWAR (trifluoroacetate salt)

Item No. 24700

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,4-dinitrophenyl)-L-prolyl-L-leucyl-L-alanyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-arginine, 2,2,2-trifluoroacetate
Synonyms
  • Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH
  • Matrix Metalloproteinase-8/Matrix Metalloproteinase-26 Fluorogenic Substrate
  • MMP-8/MMP-26 Fluorogenic Substrate
Molecular Formula
C49H63N13O13 • XCF3COOH
Formula Weight
1042.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C([C@H](C)NC([C@H](CC(C)C)NC([C@H]1N(C2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)CCC1)=O)=O)N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC4=CNC5=C4C=CC=C5)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C49H63N13O13.C2HF3O2/c1-26(2)21-36(59-47(69)40-12-8-20-60(40)39-18-15-31(61(72)73)24-41(39)62(74)75)44(66)54-28(4)43(65)57-37(22-29-13-16-32(63)17-14-29)46(68)58-38(23-30-25-53-34-10-6-5-9-33(30)34)45(67)55-27(3)42(64)56-35(48(70)71)11-7-19-52-49(50)51;3-2(4,5)1(6)7/h5-6,9-10,13-18,24-28,35-38,40,53,63H,7-8,11-12,19-23H2,1-4H3,(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,68)(H,59,69)(H,70,71)(H4,50,51,52);(H,6,7)/t27-,28-,35-,36-,37-,38-,40-;/m0./s1
InChi Key
LZCVLSCLDFIVLH-FDXVXMCESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $55

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    1 mg

    $105

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    Product Description

    Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26.1,2 The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Netzel-Arnett, S., Mallya, S.K., Nagase, H., et al. Continuously recording fluorescent assays optimized for five human matrix metalloproteinases. Anal. Biochem. 195(1), 86-92 (1991).

    2. Park, H.I., Turk, B.E., Gerkema, F.E., et al. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. The Journal of Biological Chemisty 277(38), 35168-35175 (2002).