A substrate for pancreatic elastase
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Suc-AAP-Abu-pNA (trifluoroacetate salt)

Item No. 24704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-2-amino-butanamide, trifluoroacetate salt
Synonyms
  • Elastase Colorimetric Substrate IV
Molecular Formula
C25H34N6O9 • XCF3COOH
Formula Weight
562.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(N[C@H](C(NC1=CC=C([N+]([O-])=O)C=C1)=O)CC)[C@H]2N(C([C@H](C)NC([C@@H](NC(CCC(O)=O)=O)C)=O)=O)CCC2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C25H34N6O9.C2HF3O2/c1-4-18(23(36)28-16-7-9-17(10-8-16)31(39)40)29-24(37)19-6-5-13-30(19)25(38)15(3)27-22(35)14(2)26-20(32)11-12-21(33)34;3-2(4,5)1(6)7/h7-10,14-15,18-19H,4-6,11-13H2,1-3H3,(H,26,32)(H,27,35)(H,28,36)(H,29,37)(H,33,34);(H,6,7)/t14-,15-,18-,19-;/m0./s1
InChi Key
PZVPMRAKSVWLCW-RFFPBCEMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $69

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    1 mg

    $127

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    Product Description

    Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase.1,2 It is cleaved by elastase to release p-nitroalinide (p-NA), which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Del Mar, E.G., Largman, C., Brodrick, J.W., et al. Substrate specificity of human pancreatic elastase 2. Biochemistry 19(3), 468-472 (1980).

    2. Largman, C. Isolation and characterization of rat pancreatic elastase. Biochemistry 22(16), 3763-3770 (1983).