A neurotensin-like neuropeptide
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Neuromedin N (trifluoroacetate salt)

Item No. 24707

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine, trifluoroacetate salt
Synonyms
  • NMN
Molecular Formula
C38H63N7O8 • XCF3COOH
Formula Weight
745.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C38H63N7O8.C2HF3O2/c1-7-23(5)31(36(50)42-29(38(52)53)20-22(3)4)43-34(48)28(21-25-14-16-26(46)17-15-25)41-35(49)30-13-11-19-45(30)37(51)32(24(6)8-2)44-33(47)27(40)12-9-10-18-39;3-2(4,5)1(6)7/h14-17,22-24,27-32,46H,7-13,18-21,39-40H2,1-6H3,(H,41,49)(H,42,50)(H,43,48)(H,44,47)(H,52,53);(H,6,7)/t23-,24-,27-,28-,29-,30-,31-,32-;/m0./s1
InChi Key
LBLMAXWHYUDNTA-VDQDBXMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    Product Description

    Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin.1 It is highly expressed in the brain but is also expressed in the gastrointestinal system and adrenal glands. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin (IC50s = 16.7 and 3 nM, respectively).2 Neuromedin N (10 pM) increases the phagocytic function of isolated murine peritoneal macrophages and increases chemotaxis two-fold compared with control, an effect that is blocked by the calcium-channel blocker ryanodine.3 It induces hypotension in rats and contraction of isolated guinea pig ileum.4 Neuromedin N (0.05 - 5 μg, i.c.v.) also elicits hypothermia in rats in a dose- and time-dependent manner, which is potentiated by bestatin (Item No. 21217).5 Neuromedin N is more potent than neurotensin in stimulating spontaneous motor activity and increasing dopamine metabolism in several brain regions following injection into the rat ventral tegmental area but is less potent than neurotensin when injected into the nucleus accumbens.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kitabgi, P. Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines. Results Probl. Cell Differ. 50, 85-96 (2010).

    2. Checler, F., Vincent, J.P., and Kitabgi, P. Neuromedin N: High affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur. J. Pharmacol. 126(3), 239-244 (1986).

    3. De la Fuente, M., Garrido, J.J., Arahuetes, R.M., et al. Stimulation of phagocytic function in mouse macrophages by neurotensin and neuromedin N. J. Neuroimmunol. 42(1), 97-104 (1993).

    4. Minamino, N., Kangawa, K., and Matsuo, H. Neuromedin N: A novel neurotensin-like peptide identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 122(2), 542-549 (1984).

    5. Dubuc, I., Nouel, D., Coquerel, A., et al. Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur. J. Pharmacol. 151(1), 117-121 (1988).

    6. Kalivas, P.W., Richardson-Carlson, R., and Duffy, P. Neuromedin N mimics the actions of neurotensin in the ventral tegmental area but not in the nucleus accumbens. J. Pharmacol. Exp. Ther. 238(3), 1126-1131 (1986).