A peptide agonist of the α-thrombin receptor
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Thrombin Receptor Agonist Peptide (trifluoroacetate salt)

Item No. 24710

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-L-prolyl-L-asparaginyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-α-glutamyl-L-prolyl-L-phenylalanine, trifluoroacetate salt
Synonyms
  • TRAP-14
Molecular Formula
C81H118N20O23 • XCF3COOH
Formula Weight
1739.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N1CCC[C@H]1C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N2CCC[C@H]2C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C81H118N20O23.C2HF3O2/c1-43(2)34-53(93-71(114)54(35-44(3)4)94-73(116)55(92-67(110)49(83)42-102)36-45-16-7-5-8-17-45)70(113)90-51(21-13-31-88-81(86)87)69(112)98-59(40-64(85)105)79(122)101-33-15-22-61(101)76(119)97-57(39-63(84)104)74(117)96-58(41-66(108)109)75(118)89-50(20-11-12-30-82)68(111)95-56(37-47-24-26-48(103)27-25-47)72(115)91-52(28-29-65(106)107)78(121)100-32-14-23-62(100)77(120)99-60(80(123)124)38-46-18-9-6-10-19-46;3-2(4,5)1(6)7/h5-10,16-19,24-27,43-44,49-62,102-103H,11-15,20-23,28-42,82-83H2,1-4H3,(H2,84,104)(H2,85,105)(H,89,118)(H,90,113)(H,91,115)(H,92,110)(H,93,114)(H,94,116)(H,95,111)(H,96,117)(H,97,119)(H,98,112)(H,99,120)(H,106,107)(H,108,109)(H,123,124)(H4,86,87,88);(H,6,7)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-;/m0./s1
InChi Key
FLLYJONFQXZTEB-BFAJEKHBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor.1 It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma.2 TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline.1 It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α-thrombin. TRAP-14 also induces contraction of isolated rat aortic rings and increases endothelin-1 (ET-1) levels in a dose-dependent manner, an effect that is reversed by the ETA antagonist BQ-123 and the nitric oxide synthase (NOS) inhibitor L-NNA (Item No. 80220).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lum, H., Andersen, T.T., Fenton, J.W., II, et al. Thrombin receptor activation peptide induces pulmonary vasoconstriction. Am. J. Physiol. 266(2 Pt. 1), C448-C454 (1994).

    2. Gulsa, E., Paintz, M., Zucker, T.P., et al. Thrombin receptor activating peptide-induced cellular effects: comparative studies on human platelet activation and endothelium-dependent relaxation of porcine pulmonary arteries. Agents Actions Suppl. 45, 303-307 (1995).

    3. Magazine, H.I., Butt, O., and Yaghoutiel, H.R. Endothelin and nitric oxide release modulate aortic contraction to selected thrombin receptor agonists. Am. J. Physiol. 270(6 Pt. 1), C1815-C1818 (1996).