A neuropeptide agonist of the urotensin II receptor
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Urotensin II (human) (trifluoroacetate salt)

Item No. 24711

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5→10)-disulfide, trifluoroacetate salt
Synonyms
  • hU II
Molecular Formula
C64H85N13O18S2 • XCF3COOH
Formula Weight
1388.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
[H]N[C@@H](CCC(O)=O)C(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C2=O)CC3=CC=C(O)C=C3)=O)=O)CC4=CNC5=C4C=CC=C5)=O)CC6=CC=CC=C6)=O)CSSC[C@H](N2)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C64H85N13O18S2.C2HF3O2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36;3-2(4,5)1(6)7/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95);(H,6,7)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+;/m1./s1
InChi Key
MBEBYNOGELTOBF-SWXJRECRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $241

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    Product Description

    Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).1 It increases intracellular calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM). Urotensin II increases the level of reactive oxygen species (ROS) in pulmonary artery smooth muscle cells and induces proliferation, an effect that is inhibited by depletion of NADPH oxidase subunits.2 Urotensin II potently induces contraction of isolated rat thoracic aorta with an EC50 of 0.8 nM.1 It also induces contraction of isolated cynomolgus monkey arterial, but not venous, vessels and, when administered at doses greater than 100 pmol/kg, can lead to severe myocardial depression and fatal circulatory collapse.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ames, R.S., Sarau, H.M., Chambers, J.K., et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401(6750), 282-286 (1999).

    2. Zeng, H., Liu, G., Rea, P.A., et al. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 60(17), 4779-4784 (2000).