An NPY receptor agonist
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[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt)

Item No. 24712

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
31-L-leucine-34-L-proline-neuropeptide Y (human), trifluoroacetate salt
Synonyms
  • [Leu31,Pro34] NPY
Molecular Formula
C189H284N54O56S • XCF3COOH
Formula Weight
4240.7
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(CNC([C@@H]3CCCN3C([C@H](CC(N)=O)NC([C@@H](NC([C@@H]4CCCN4C([C@H](CCCCN)NC([C@H](CO)NC([C@@H]5CCCN5C([C@@H](N[H])CC6=CC=C(O)C=C6)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)C)=O)=O)CC(O)=O)=O)CCSC)=O)C)=O)=O)CC7=CC=C(O)C=C7)=O)CC8=CC=C(O)C=C8)=O)=O)C)=O)=O)=O)CC9=CN=CN9)=O)CC%10=CC=C(O)C=C%10)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC%11=CC=C(O)C=C%11)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C189H284N54O56S.C2HF3O2/c1-15-95(8)149(179(293)233-129(82-141(192)252)167(281)224-123(74-93(4)5)163(277)225-124(75-94(6)7)170(284)238-150(100(13)246)180(294)221-120(31-21-66-207-189(201)202)184(298)242-70-25-35-139(242)176(290)219-115(30-20-65-206-188(199)200)156(270)222-121(151(194)265)77-102-39-49-108(248)50-40-102)237-171(285)127(80-105-45-55-111(251)56-46-105)228-166(280)128(81-106-87-203-91-209-106)229-158(272)114(29-19-64-205-187(197)198)217-162(276)122(73-92(2)3)223-154(268)97(10)211-172(286)134(89-244)235-165(279)126(79-104-43-53-110(250)54-44-104)227-164(278)125(78-103-41-51-109(249)52-42-103)226-157(271)113(28-18-63-204-186(195)196)215-152(266)96(9)210-155(269)118(61-72-300-14)218-168(282)131(85-147(261)262)231-160(274)117(58-60-145(257)258)216-153(267)98(11)212-175(289)137-33-23-67-239(137)181(295)99(12)213-161(275)130(84-146(259)260)230-159(273)116(57-59-144(255)256)214-143(254)88-208-174(288)136-32-22-69-241(136)185(299)133(83-142(193)253)234-169(283)132(86-148(263)264)232-177(291)140-36-26-71-243(140)183(297)119(27-16-17-62-190)220-173(287)135(90-245)236-178(292)138-34-24-68-240(138)182(296)112(191)76-101-37-47-107(247)48-38-101;3-2(4,5)1(6)7/h37-56,87,91-100,112-140,149-150,244-251H,15-36,57-86,88-90,190-191H2,1-14H3,(H2,192,252)(H2,193,253)(H2,194,265)(H,203,209)(H,208,288)(H,210,269)(H,211,286)(H,212,289)(H,213,275)(H,214,254)(H,215,266)(H,216,267)(H,217,276)(H,218,282)(H,219,290)(H,220,287)(H,221,294)(H,222,270)(H,223,268)(H,224,281)(H,225,277)(H,226,271)(H,227,278)(H,228,280)(H,229,272)(H,230,273)(H,231,274)(H,232,291)(H,233,293)(H,234,283)(H,235,279)(H,236,292)(H,237,285)(H,238,284)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207);(H,6,7)/t95-,96-,97-,98-,99-,100+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,149-,150-;/m0./s1
InChi Key
UTXYOYRRGHNRPM-LOLOGDOISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    [Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors.1 It reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s = 29.5 and 2.95 nM, respectively). 2 It also binds to rhesus monkey Y2 and mouse Y6 receptors (Kis = 410 and 9.7 nM, respectively).1,3 In vitro, [Leu31,Pro34] NPY increases cellular protein mass by 25% in rat ventricular cardiomyocytes when used at a concentration of 10 nM.4 In vivo, [Leu31,Pro34] NPY (0.7-7 nmol, i.c.v.) increases food intake in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gehlert, D.R., Yang, P., George, C., et al. Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes. Peptides 22(3), 343-350 (2001).

    2. Walker, M.W., Smith, K.E., Bard, J., et al. A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide. Peptides 18(4), 609-612 (1997).

    3. Mullins, D.E., Guzzi, M., Xia, L., et al. Pharmacological characterization of the cloned neuropeptide Y y6 receptor. Eur. J. Pharmacol. 395(2), 87-93 (2000).

    4. Nicholl, S.M., Bell, D., Spiers, J.P., et al. Neuropeptide Y Y1 receptor regulates protein turnover and constitutive gene expression in hypertrophying cardiomyocytes. Eur. J. Pharmacol. 441(1-2), 23-34 (2002).

    5. Haynes, A.C., Arch, J.R.S., Wilson, S., et al. Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: A role for the Y5 receptor? Regul. Pept. 75-76, 355-361 (1998).