A free acid form of NPY
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Product Type

Biochemicals
Peptides
Neuropeptides

Research Area

Neuropeptide Y (human, rat) (free acid) (trifluoroacetate salt)

Item No. 24716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • NPY (human, rat)
Molecular Formula
C189H284N54O58S • XCF3COOH
Formula Weight
4272.7
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N1CCC[C@H]1C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N2CCC[C@H]2C(N[C@H](C(N[C@@H](CC(N)=O)C(N3CCC[C@H]3C(NCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N4CCC[C@H]4C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)CC7=CN=CN7)=O)=O)=O)C)=O)=O)CC8=CC=C(O)C=C8)=O)CC9=CC=C(O)C=C9)=O)=O)C)=O)CCSC)=O)CC(O)=O)=O)=O)C)=O)=O)C)=O)CC(O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CC%10=CC=C(O)C=C%10.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C189H284N54O58S.C2HF3O2/c1-15-93(7)148(178(293)232-127(81-140(193)253)167(282)224-122(74-92(5)6)170(285)238-149(94(8)16-2)179(294)239-150(99(13)246)180(295)221-115(31-22-67-207-189(201)202)155(270)219-117(56-59-139(192)252)160(275)217-114(30-21-66-206-188(199)200)158(273)234-132(185(300)301)79-104-44-54-110(251)55-45-104)237-171(286)125(78-103-42-52-109(250)53-43-103)227-166(281)126(80-105-86-203-90-209-105)228-157(272)113(29-20-65-205-187(197)198)218-163(278)121(73-91(3)4)223-153(268)96(10)211-172(287)133(88-244)235-165(280)124(77-102-40-50-108(249)51-41-102)226-164(279)123(76-101-38-48-107(248)49-39-101)225-156(271)112(28-19-64-204-186(195)196)215-151(266)95(9)210-154(269)119(62-72-302-14)220-168(283)129(84-146(262)263)230-161(276)118(58-61-144(258)259)216-152(267)97(11)212-175(290)136-33-24-68-240(136)181(296)98(12)213-162(277)128(83-145(260)261)229-159(274)116(57-60-143(256)257)214-142(255)87-208-174(289)135-32-23-70-242(135)184(299)131(82-141(194)254)233-169(284)130(85-147(264)265)231-176(291)138-35-26-71-243(138)183(298)120(27-17-18-63-190)222-173(288)134(89-245)236-177(292)137-34-25-69-241(137)182(297)111(191)75-100-36-46-106(247)47-37-100;3-2(4,5)1(6)7/h36-55,86,90-99,111-138,148-150,244-251H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,252)(H2,193,253)(H2,194,254)(H,203,209)(H,208,289)(H,210,269)(H,211,287)(H,212,290)(H,213,277)(H,214,255)(H,215,266)(H,216,267)(H,217,275)(H,218,278)(H,219,270)(H,220,283)(H,221,295)(H,222,288)(H,223,268)(H,224,282)(H,225,271)(H,226,279)(H,227,281)(H,228,272)(H,229,274)(H,230,276)(H,231,291)(H,232,293)(H,233,284)(H,234,273)(H,235,280)(H,236,292)(H,237,286)(H,238,285)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207);(H,6,7)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-;/m0./s1
InChi Key
MUALCWKXFKYGDS-ABHXLKRPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $222

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    1 mg

    $399

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    Product Description

    Neuropeptide Y (NPY) is a neuropeptide abundantly distributed throughout the central and peripheral nervous systems that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.1 The free acid form of NPY is less potent than NPY at inhibiting forskolin-induced cAMP accumulation in cultured bovine adrenal chromaffin cells.2 Injection of the free acid form of NPY (78-235 pmol) into the paraventricular nucleus (PVN) of the hypothalamus of satiated rats does not alter food intake.3 Unlike NPY, the free acid form has no effect on memory retention in a T-maze foot-shock avoidance test in mice when administered at a dose of 5 µg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balasubramaniam, A. Neuropeptide Y family of hormones: Receptor subtypes and antagonists. Peptides 18(3), 445-457 (1997).

    2. Zhu, J., Li, W., Toews, M.L., et al. Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process. J. Pharmacol. Exp. Ther. 263(3), 1479-1486 (1992).

    3. Stanley, B.G., Magdalin, W., Seirafi, A., et al. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide’s effect. Peptides 13(3), 581-587 (1992).

    4. Flood, J.F., Hernandez, E.N., and Morley, J.E. Modulation of memory processing by neuropeptide Y. Brain Res. 421(1-2), 280-290 (1987).