A neuropeptide with diverse biological activities
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Neurotensin (trifluoroacetate salt)

Item No. 24717

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C78H121N21O20 • XCF3COOH
Formula Weight
1672.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
CC(C[C@H](NC([C@H]1NC(CC1)=O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(N[C@H](C(N[C@](C(N[C@@H](CC(C)C)C(O)=O)=O)([C@H](CC)C)[H])=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)C.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C78H121N21O20.C2HF3O2/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49;3-2(4,5)1(6)7/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86);(H,6,7)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-;/m0./s1
InChi Key
VJEACBVKQVCKGH-PLGSVMMTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    Product Description

    Neurotensin is a neuropeptide that is distributed throughout the CNS and in enteroendocrine cells of the small intestine that has diverse biological activities.1,2,3,4 In vivo, neurotensin (10-50 μg per hour, i.c.v.) induces hypothermia in rats.2 Neurotensin signaling is increased and induces analgesia in wild-type mice, and neurotensin knockout mice are defective in basal nociceptive and stress-induced analgesic responses in a cold water swim stress test.3 It acts as an indirect dopamine antagonist that inhibits dopamine-induced effects at pre- and postsynaptic dopamine receptors.4 Neurotensin inhibits small bowel motility and secretion of gastric acid, stimulates pancreatic and biliary secretion, increases fatty acid absorption, and stimulates growth of the stomach, colon, pancreas, and small bowel in rats.1 It also increases growth of breast, pancreatic, and hepatocellular carcinoma cells via induction of IL-8 secretion and activation of epithelial mesenchymal transition (EMT) in vitro and in vivo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ye, T., Liu, P., Wang, Y., et al. Neurotensin, a novel messenger to cross-link inflammation and tumor invasion via epithelial-mesenchymal transition pathway. Int. Rev. Immunol. 35(4), 340-350 (2016).

    2. Popp, E., Schneider, A., Vogel, P., et al. Time course of the hypothermic response to continuously administered neurotensin. Neuropeptides 41(5), 349-354 (2007).

    3. Dobner, P.R. Neurotensin and pain modulation. Peptides 27(10), 2405-2414 (2006).

    4. Kitabgi, P. Neurotensin modulates dopamine neurotransmission at several levels along brain dopaminergic pathways. Neurochem Int. 14(2), 111-119 (1989).