AcrB (E. coli K12)

AcrB is an inner membrane-associated transporter and component of the constitutively expressed, multidrug efflux system AcrAB in E. coli.¹ It forms a complex with periplasmic and oligomeric AcrA in the presence and absence of the outer membrane component TolC to directly transport substrates from the cell interior to the periplasm. AcrB is encoded by acrAB which is upregulated in multiple-antibiotic-resistant E. coli strains, and deletion of acrAB increases E. coli susceptibility to various antibiotics (MICs = 1.25-100 and 0.3-5 mg/l for wild-type and DacrAB E. coli strains, respectively).²

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1. Zgurskaya, H.I., and Nikaido, H. Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. J. Bacteriol. 182(15), 4264-4267 (2000).

2. Okusu, H., Ma, D., and Nikaido, H. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178(1), 306-308 (1996).