A peptide precursor of angiotensin II and an angiotensin receptor ligand
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Angiotensin I (human, rat, mouse) (trifluoroacetate salt)

Item No. 24737

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-L-isoleucine-angiotensin I, trifluroracetate salt
Molecular Formula
C62H89N17O14 • XCF3COOH
Formula Weight
1296.5
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
C[C@@H](CC)[C@]([H])(NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC1=CC=C(C=C1)O)=O)C(N[C@@H](CC2=CNC=N2)C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CC4=CN=CN4)=O)CC5=CC=CC=C5)=O)CCC3)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C62H89N17O14.C2HF3O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;3-2(4,5)1(6)7/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);(H,6,7)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-;/m0./s1
InChi Key
XMNUWKLIJQRDTJ-AHYCRNLZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $165

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    10 mg

    $264

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    Product Description

    Angiotensin I is an endogenous peptide that is converted to the vasoconstrictor angiotensin II (Item No. 17150) by angiotensin-converting enzyme (ACE).1 It binds to angiotensin receptors in human myometrium membrane preparations (Kd = 11.2 nM) and increases renal vascular resistance in isolated rat kidney (EC50 = 10.5 nM).2,3 In vivo, angiotensin I (5 μg/kg, i.c.v.) increases mean arterial pressure (MAP) and plasma arginine vasopressin (AVP) level in fetal ewes.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Z., Tan, F., Erdös, E.G., et al. Hydrolysis of angiotensin peptides by human angiotensin I-converting enzyme and the resensitization of B2 kinin receptors. Hypertension 46(6), 1368-1373 (2005).

    2. Bouley, R., Pérodin, J., Plante, H., et al. N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor. Eur. J. Pharmacol. 343(2-3), 323-331 (1998).

    3. Schmidt, M., Giesen-Grouse, E.-M., Krieger, J.-P., et al. Effect of angiotensin converting enzyme inhibitors on the vasoconstrictor action of angiotensin I on isolated rat kidney. J. Cardiovasc. Pharmacol. 8(suppl 10), S100-S105 (1986).

    4. Shi, L., Mao, C., Zeng, F., et al. Central angiotensin I increases fetal AVP neuron activity and pressor responses. Am. J. Physiol. Endocrinol. Metab. 298(6), E1274-E1282 (2010).