A peptide vasoconstrictor
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Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)

Item No. 24738

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-L-isoleucine-3-8-angiotensin II, trifluoroacetate salt
Synonyms
  • Angiotensin IV (human, rat, mouse)
Molecular Formula
C40H54N8O8 • XCF3COOH
Formula Weight
774.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
C[C@@H](CC)[C@]([H])(NC([C@@H](NC([C@H](C(C)C)N)=O)CC1=CC=C(C=C1)O)=O)C(N[C@@H](CC2=CNC=N2)C(N3[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CCC3)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C40H54N8O8.C2HF3O2/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25;3-2(4,5)1(6)7/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56);(H,6,7)/t24-,29-,30-,31-,32-,33-,34-;/m0./s1
InChi Key
FCDOCNHFFAOXJR-BPXNUQSUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    Product Description

    Angiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II (Item No. 17150).1 It selectively binds to the angiotensin 2 (AT2) over AT1 receptors (IC50s = 48.6 and >1,000 nM, respectively, in HEK293 cells expressing rat receptors). It also binds to AT4 receptors in bovine aortic endothelial cell membranes (IC50 = 1.6 nM).2 Angiotensin II (3-8) induces a positive chronotropic effect in isolated rat right atria (EC50 = 4.68 μM) and increases mean arterial pressure (MAP) in vivo in rats when administrated intracerebroventricularly at a dose of 1 pmol.3,4 It also increases latency to withdrawal in a tail-flick test in rats when administered by microinjection into the ventrolateral periaqueductal gray (vlPAG).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bosnyak, S., Jones, E.S., Christopoulos, A., et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin. Sci. (Lond.) 121(7), 297-303 (2011).

    2. Bernier, S.G., Bellemare, J.M., Escher, E., et al. Characterization of AT4 receptor from bovine aortic endothelium with photosensitive analogues of angiotensin IV. Biochemistry 37(12), 4280-4287 (1998).

    3. Li, Q., Zhang, J., Pfaffendorf, M., et al. Direct positive chronotropic effects of angiotensin II and angiotensin III in pithed rats and in rat isolated atria. Br. J. Pharmacol. 118(7), 1653-1658 (1996).

    4. Wright, J.W., Jensen, L.L., Roberts, K.A., et al. Structure-function analyses of brain angiotensin control of pressor action in rats. Am. J. Physiol. 257(6 Pt. 2), R1551-R1557 (1989).

    5. Guethe, L.M., Pelegrini-da-Silva, A., Borelli, K.G., et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience 231, 315-327 (2013).