A neuropeptide
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Cortistatin-29 (rat) (trifluoroacetate salt)

Item No. 24740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolyl-L-α-glutamyl-L-arginyl-L-prolyl-L-prolyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-prolyl-L-histidyl-L-arginyl-L-α-aspartyl-L-lysyl-L-lysyl-L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-L-lysine, cyclic (17→28)-disulfide, trifluoroacetate salt
CAS Number
1815618-17-7
Molecular Formula
C161H240N46O41S2 • XCF3COOH
Formula Weight
3540.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(CC[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N4CCC[C@H]4C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(N[C@@H](CSSC[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)N7)C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CC%10=CNC%11=C%10C=CC=C%11)C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC%12=CC=CC=C%12)C(N[C@H](C(N[C@H](C7=O)CO)=O)CO)=O)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O)=O)CC(N)=O)=O)CCCCN)=O)=O)=O)CCCCN)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)=O)=O)CCCNC(N)=N)=O)NC([C@H]%13NC(CC%13)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C161H240N46O41S2.C2HF3O2/c1-87(2)72-107(195-150(238)120-48-28-68-204(120)157(245)122-50-30-70-206(122)155(243)104(46-26-66-176-161(172)173)187-136(224)102(55-59-128(215)216)184-134(222)100-54-58-127(214)179-100)138(226)185-101(52-56-124(167)211)135(223)188-105(53-57-125(168)212)156(244)207-71-31-51-123(207)158(246)205-69-29-49-121(205)151(239)196-112(77-93-81-174-86-178-93)143(231)182-99(45-25-65-175-160(170)171)133(221)194-114(79-129(217)218)145(233)180-96(40-15-20-60-162)131(219)186-103(43-18-23-63-165)154(242)203-67-27-47-119(203)152(240)201-118-85-250-249-84-117(149(237)189-106(159(247)248)44-19-24-64-166)200-147(235)116(83-209)199-146(234)115(82-208)198-141(229)110(75-91-36-11-6-12-37-91)197-153(241)130(88(3)210)202-137(225)98(42-17-22-62-164)181-142(230)111(76-92-80-177-95-39-14-13-38-94(92)95)192-140(228)109(74-90-34-9-5-10-35-90)190-139(227)108(73-89-32-7-4-8-33-89)191-144(232)113(78-126(169)213)193-132(220)97(183-148(118)236)41-16-21-61-163;3-2(4,5)1(6)7/h4-14,32-39,80-81,86-88,96-123,130,177,208-210H,15-31,40-79,82-85,162-166H2,1-3H3,(H2,167,211)(H2,168,212)(H2,169,213)(H,174,178)(H,179,214)(H,180,233)(H,181,230)(H,182,231)(H,183,236)(H,184,222)(H,185,226)(H,186,219)(H,187,224)(H,188,223)(H,189,237)(H,190,227)(H,191,232)(H,192,228)(H,193,220)(H,194,221)(H,195,238)(H,196,239)(H,197,241)(H,198,229)(H,199,234)(H,200,235)(H,201,240)(H,202,225)(H,215,216)(H,217,218)(H,247,248)(H4,170,171,175)(H4,172,173,176);(H,6,7)/t88-,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,130+;/m1./s1
InChi Key
PQFBCGMUTNPFPG-FBYJJCAGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $224

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    Product Description

    Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28.1 It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex.1,2 Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively.2 Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Lecea, L., Criado, J.R., Prospero-Garcia, O., et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381(6579), 242-245 (1996).

    2. Spier, A.D., and de Lecea, L. Cortistatin: A member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. Brain Res. Rev. 33(2-3), 228-241 (2000).