A peptide agonist of CRF1 and CRF2
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Urotensin I (white sucker) (trifluoroacetate salt)

Item No. 24752

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparaginyl-L-α-aspartyl-L-α-aspartyl-L-prolyl-L-prolyl-L-isoleucyl-L-seryl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-L-methionyl-L-isoleucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-arginyl-L-α-glutamyl-L-glutaminyl-L-alanylglycyl-L-leucyl-L-asparaginyl-L-arginyl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-α-glutamyl-L-valinamide, trifluoroacetate salt
Molecular Formula
C210H340N62O67S2 • XCF3COOH
Formula Weight
4869.5
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC(CNC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@H](CC(N)=O)N[H])=O)CC(O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)CCSC)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C210H340N62O67S2.C2HF3O2/c1-26-103(17)162(200(333)249-124(58-64-155(288)289)180(313)258-136(86-148(215)278)192(325)244-122(56-62-153(284)285)177(310)239-116(44-35-69-228-207(219)220)174(307)243-121(55-61-152(282)283)178(311)242-120(54-60-146(213)276)171(304)234-107(21)168(301)232-94-151(281)236-128(77-97(5)6)184(317)259-138(88-150(217)280)191(324)241-117(45-36-70-229-208(221)222)173(306)238-115(43-33-34-68-211)175(308)255-133(83-111-50-52-113(275)53-51-111)188(321)252-131(80-100(11)12)187(320)260-140(90-158(294)295)194(327)245-125(59-65-156(290)291)182(315)265-161(102(15)16)167(218)300)266-181(314)119(47-38-72-231-210(225)226)237-169(302)108(22)235-172(305)126(66-75-340-24)246-179(312)123(57-63-154(286)287)248-201(334)163(104(18)27-2)267-183(316)127(67-76-341-25)247-193(326)137(87-149(216)279)257-176(309)118(46-37-71-230-209(223)224)240-185(318)129(78-98(7)8)251-186(319)130(79-99(9)10)253-190(323)135(84-112-93-227-96-233-112)256-189(322)134(82-110-41-31-30-32-42-110)261-204(337)166(109(23)274)270-197(330)132(81-101(13)14)254-195(328)141(91-159(296)297)262-202(335)164(105(19)28-3)268-198(331)143(95-273)264-203(336)165(106(20)29-4)269-199(332)144-48-39-73-271(144)206(339)145-49-40-74-272(145)205(338)142(92-160(298)299)263-196(329)139(89-157(292)293)250-170(303)114(212)85-147(214)277;3-2(4,5)1(6)7/h30-32,41-42,50-53,93,96-109,114-145,161-166,273-275H,26-29,33-40,43-49,54-92,94-95,211-212H2,1-25H3,(H2,213,276)(H2,214,277)(H2,215,278)(H2,216,279)(H2,217,280)(H2,218,300)(H,227,233)(H,232,301)(H,234,304)(H,235,305)(H,236,281)(H,237,302)(H,238,306)(H,239,310)(H,240,318)(H,241,324)(H,242,311)(H,243,307)(H,244,325)(H,245,327)(H,246,312)(H,247,326)(H,248,334)(H,249,333)(H,250,303)(H,251,319)(H,252,321)(H,253,323)(H,254,328)(H,255,308)(H,256,322)(H,257,309)(H,258,313)(H,259,317)(H,260,320)(H,261,337)(H,262,335)(H,263,329)(H,264,336)(H,265,315)(H,266,314)(H,267,316)(H,268,331)(H,269,332)(H,270,330)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,
InChi Key
SBHLDQHFGWBZRI-UUHBHRNYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $242

    Add

    1 mg

    $363

    Add
    Product Description

    Urotensin I is a peptide agonist of corticotropin-releasing factor receptor 1 (CRF1) and CRF2 and is involved in the regulation of cortisol and stress responses in teleost fish.1 It is expressed in the urophysis or the brain in teleost fish and has also been found in elasmobranchii fish.2 It induces cAMP production in HEK293 cells expressing human CRF1 or CRF2α (EC50s = 0.52 and 0.6 nM, respectively) or Xenopus CRF1 or CRF2 (EC50s = 0.78 and 0.46 nM, respectively).3 Urotensin I stimulates thyroid stimulating hormone (TSH) release in primary coho salmon pituitary cells when used at concentrations ranging from 0.01 to 100 nM.4 The expression of urotensin I increases in the preoptic area and urophysis of rainbow trout in response to isolation and hyperammonia stress, respectively, and correlates with plasma cortisol levels in masu salmon.5,6 Urotensin I suppresses food intake in rainbow trout (ED50 = 17.4 ng/g).7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mimassi, N., Shahbazi, F., Jensen, J., et al. Cardiovascular actions of centrally and peripherally administered trout urotensin-I in the trout. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279(2), R484-R491 (2000).

    2. Amano, M. Subchapter 4B - Urotensin I. Handbook of hormones 1, 45-47 (2021).

    3. Dautzenberg, F.M., Py-Lang, G., Higelin, J., et al. Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: Evidence for evolutionary differences. J. Pharmacol. Exp. Ther. 296(1), 113-120 (2001).

    4. Larsen, D.A., Swanson, P., Dickey, J.T., et al. In vitro thyrotropin-releasing activity of corticotropin-releasing hormone-family peptides in coho salmon, Oncorhynchus kisutch. Gen. Comp. Endocrinol. 109(2), 276-285 (1998).

    5. Bernier, N.J., Alderman, S.L., and Bristow, E.N. Heads or tails? Stressor-specific expression of corticotropin-releasing factor and urotensin I in the preoptic area and caudal neurosecretory system of rainbow trout. J. Endocrinol. 196(3), 637-648 (2008).

    6. C.G., W., Ando, H., Kitahashi, T., et al. Seasonal changes in CRF-I and urotensin I transcript levels in masu salmon: Correlation with cortisol secretion during spawning. Gen. Comp. Endocrinol. 155(1), 126-140 (2008).

    7. Ortega, V.A., Lovejoy, D.A., and Bernier, N.J. Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss). Front. Neurosci. 7:196, (2013).