A synthetic form of the peptide GLP-2
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GLP-2 (1-34) (human) (trifluoroacetate salt)

Item No. 24756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-L-alanyl-L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-alanyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-α-aspartyl-L-arginine, trifluoroacetate salt
Synonyms
  • Glucagon-like Peptide 2 (1-34)
Molecular Formula
C171H266N48O56S • XCF3COOH
Formula Weight
3922.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O)CC(O)=O)=O)=O)C)=O)C)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)CC(O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC(O)=O)=O)C)=O)CC5=CN=CN5.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C171H266N48O56S.C2HF3O2/c1-22-80(11)130(162(267)196-99(47-49-119(174)225)146(251)217-134(87(18)222)166(271)195-97(44-34-35-52-172)145(250)213-133(83(14)25-4)165(270)219-135(88(19)223)167(272)211-116(70-129(240)241)154(259)197-102(169(274)275)46-37-54-184-171(180)181)214-157(262)105(58-79(9)10)200-150(255)108(61-92-71-185-96-43-33-32-42-94(92)96)203-152(257)110(64-121(176)227)210-163(268)131(81(12)23-2)215-158(263)107(60-91-40-30-27-31-41-91)201-155(260)114(68-127(236)237)206-142(247)98(45-36-53-183-170(178)179)192-138(243)85(16)188-137(242)84(15)190-147(252)103(56-77(5)6)199-151(256)109(63-120(175)226)205-156(261)115(69-128(238)239)207-148(253)104(57-78(7)8)209-164(269)132(82(13)24-3)216-168(273)136(89(20)224)218-159(264)111(65-122(177)228)204-144(249)101(51-55-276-21)194-143(248)100(48-50-124(230)231)193-153(258)113(67-126(234)235)208-161(266)118(75-221)212-149(254)106(59-90-38-28-26-29-39-90)202-160(265)117(74-220)191-123(229)73-186-141(246)112(66-125(232)233)198-139(244)86(17)189-140(245)95(173)62-93-72-182-76-187-93;3-2(4,5)1(6)7/h26-33,38-43,71-72,76-89,95,97-118,130-136,185,220-224H,22-25,34-37,44-70,73-75,172-173H2,1-21H3,(H2,174,225)(H2,175,226)(H2,176,227)(H2,177,228)(H,182,187)(H,186,246)(H,188,242)(H,189,245)(H,190,252)(H,191,229)(H,192,243)(H,193,258)(H,194,248)(H,195,271)(H,196,267)(H,197,259)(H,198,244)(H,199,256)(H,200,255)(H,201,260)(H,202,265)(H,203,257)(H,204,249)(H,205,261)(H,206,247)(H,207,253)(H,208,266)(H,209,269)(H,210,268)(H,211,272)(H,212,254)(H,213,250)(H,214,262)(H,215,263)(H,216,273)(H,217,251)(H,218,264)(H,219,270)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H,274,275)(H4,178,179,183)(H4,180,181,184);(H,6,7)/t80-,81-,82-,83-,84-,85-,86-,87+,88+,89+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,130-,131-,132-,133-,134-,135-,136-;/m0./s1
InChi Key
HBLLHMZIBQOWPT-BKBWCUKCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    GLP-2 (1-34) (human) is a synthetic form of the human peptide GLP-2 (Item No. 24414) that contains the full human sequence with the addition of an arginine residue at the C-terminal end.1 It increases survival of myenteric neurons cultured alone (EC50 = 0.35 nM) and when co-cultured with mast cells to induce cell death.2 It does not stimulate insulin release from isolated rat pancreatic islets in the presence of glucose when used at concentrations ranging from 2.5 to 250 nM.1 GLP-2 (1-34) (human) also does not affect formation of adenomas in a transgenic model of intestinal tumorigenesis using ApcMin/+ mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmidt, W.E., Siegel, E.G., and Creutzfeldt, W. Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia 28(9), 704-707 (1985).

    2. Voss, U., Sand, E., Hellström, P.M., et al. Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons. BMC Gastroenterol. 12, 30 (2012).

    3. Koehler, J.A., Harper, W., Barnard, M., et al. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res. 68(19), 7897-7904 (2008).