A GnRHR agonist
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GnRH II (trifluoroacetate salt)

Item No. 24763

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-histidylglycyl-L-tryptophyl-L-tyrosyl-L-prolyl-glycinamide, trifluoroacetate salt
Synonyms
  • Gonadotropin-releasing Hormone II
  • LHRH II
Molecular Formula
C60H69N17O13 • XCF3COOH
Formula Weight
1236.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC(CNC([C@@H]1CCCN1C([C@H](CC2=CC=C(C=C2)O)NC([C@H](CC3=CNC4=C3C=CC=C4)NC(CNC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@H](CC8=CN=CN8)N(C([C@@H]9CCC(N9)=O)=O)[H])=O)=O)CO)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C60H69N17O13.C2HF3O2/c61-50(80)27-66-59(89)49-10-5-17-77(49)60(90)47(18-32-11-13-37(79)14-12-32)75-55(85)43(19-33-23-64-40-8-3-1-6-38(33)40)71-52(82)28-67-53(83)45(21-35-25-62-30-68-35)73-58(88)48(29-78)76-56(86)44(20-34-24-65-41-9-4-2-7-39(34)41)72-57(87)46(22-36-26-63-31-69-36)74-54(84)42-15-16-51(81)70-42;3-2(4,5)1(6)7/h1-4,6-9,11-14,23-26,30-31,42-49,64-65,78-79H,5,10,15-22,27-29H2,(H2,61,80)(H,62,68)(H,63,69)(H,66,89)(H,67,83)(H,70,81)(H,71,82)(H,72,87)(H,73,88)(H,74,84)(H,75,85)(H,76,86);(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-;/m0./s1
InChi Key
GPUUYIZPODSIMD-OWXBLSBESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $382

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    Product Description

    Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR).1 It binds to human recombinant type I and marmoset type II GnRHRs (IC50s = 26.1 and 1.07 nM, respectively, in COS-7 cells) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively). GnRH II stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively) and dose-dependently stimulates LH and FSH release from cultured primary rat anterior pituitary cells.2 In vivo, GnRH II (1 μg/kg, i.v.) increases plasma LH levels in White Leghorn pullets but does not affect plasma FSH levels.3 It also decreases food intake in zebrafish and increases courtship behavior in female white-crowned sparrows when administered intracerebroventricularly at doses of 1 pmol/g and 100 ng, respectively.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Millar, R., Lowe, S., Conklin, D., et al. A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc. Natl. Acad. Sci. USA 98(17), 9636-9641 (2001).

    2. Okada, Y., Murota-Kawano, A., Kakar, S.S., et al. Evidence that gonadotropin-releasing hormone (GnRH) II stimulates luteinizing hormone and follicle-stimulating hormone secretion from monkey pituitary cultures by activating the GnRH I receptor. Biol. Reprod. 69(4), 1356-1361 (2003).

    3. Proudman, J.A., Scanes, C.G., Johannsen, S.A., et al. Comparison of the ability of the three endogenous GnRHs to stimulate release of follicle-stimulating hormone and luteinizing hormone in chickens. Domest. Anim. Endocrinol. 31(2), 141-153 (2006).

    4. Nishiguchi, R., Azuma, M., Yokobori, E., et al. Gonadotropin-releasing hormone 2 suppresses food intake in the zebrafish, Danio rerio. Front. Endocrinol. (Lausanne) 3:122, (2012).

    5. Maney, D.L., Richardson, R.D., and Wingfield, J.C. Central administration of chicken gonadotropin-releasing hormone-II enhances courtship behavior in a female sparrow. Horm. Behav. 32(1), 11-18 (1997).