An acetylated form of PACAP (1-38)
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Acetyl PACAP (1-38) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt)

Item No. 24774

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-histidyl-L-seryl-L-α-aspartylglycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucylglycyl-L-lysyl-L-arginyl-L-tyrosyl-L-lysyl-L-glutaminyl-L-arginyl-L-valyl-L-lysyl-L-asparaginyl-L-lysinamide, trifluoroacetate salt
Synonyms
  • Acetyl Pituitary Adenylate Cyclase-activating Peptide (1-38)
Molecular Formula
C205H333N63O54S • XCF3COOH
Formula Weight
4576.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(C=C1)O)NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](CCSC)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(C=C4)O)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@]([H])(NC([C@H](CC5=CC=CC=C5)NC([C@@]([H])(NC(CNC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC6=CN=CN6)NC(C)=O)=O)CO)=O)=O)=O)[C@@H](C)CC)=O)=O)[C@H](O)C)=O)=O)CO)=O)=O)CO)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCC(N)=O)=O)=O)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)=O)CC(C)C)=O)=O)=O)C(C)C)=O)CC(C)C)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)=O)CC(N)=O)=O)CCCCN)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C205H333N63O54S.C2HF3O2/c1-19-110(12)164(264-158(282)100-231-171(292)149(96-159(283)284)257-196(317)153(103-271)262-190(311)147(236-115(17)273)94-121-98-225-104-232-121)200(321)259-146(89-116-41-21-20-22-42-116)193(314)268-165(114(16)272)201(322)260-150(97-160(285)286)192(313)263-152(102-270)195(316)255-145(93-120-60-68-125(277)69-61-120)189(310)261-151(101-269)194(315)245-135(52-39-84-228-204(221)222)181(302)253-143(91-118-56-64-123(275)65-57-118)187(308)244-133(50-37-82-226-202(217)218)177(298)239-128(45-25-32-77-208)174(295)247-138(71-73-155(214)279)183(304)248-139(74-86-323-18)172(293)234-113(15)169(290)265-161(107(6)7)197(318)249-131(48-28-35-80-211)176(297)240-130(47-27-34-79-210)178(299)254-144(92-119-58-66-124(276)67-59-119)188(309)251-141(88-106(4)5)185(306)235-111(13)167(288)233-112(14)168(289)266-162(108(8)9)199(320)258-140(87-105(2)3)170(291)230-99-157(281)237-127(44-24-31-76-207)173(294)241-134(51-38-83-227-203(219)220)180(301)252-142(90-117-54-62-122(274)63-55-117)186(307)243-129(46-26-33-78-209)175(296)246-137(70-72-154(213)278)182(303)242-136(53-40-85-229-205(223)224)184(305)267-163(109(10)11)198(319)250-132(49-29-36-81-212)179(300)256-148(95-156(215)280)191(312)238-126(166(216)287)43-23-30-75-206;3-2(4,5)1(6)7/h20-22,41-42,54-69,98,104-114,126-153,161-165,269-272,274-277H,19,23-40,43-53,70-97,99-103,206-212H2,1-18H3,(H2,213,278)(H2,214,279)(H2,215,280)(H2,216,287)(H,225,232)(H,230,291)(H,231,292)(H,233,288)(H,234,293)(H,235,306)(H,236,273)(H,237,281)(H,238,312)(H,239,298)(H,240,297)(H,241,294)(H,242,303)(H,243,307)(H,244,308)(H,245,315)(H,246,296)(H,247,295)(H,248,304)(H,249,318)(H,250,319)(H,251,309)(H,252,301)(H,253,302)(H,254,299)(H,255,316)(H,256,300)(H,257,317)(H,258,320)(H,259,321)(H,260,322)(H,261,310)(H,262,311)(H,263,313)(H,264,282)(H,265,290)(H,266,289)(H,267,305)(H,268,314)(H,283,284)(H,285,286)(H4,217,218,226)(H4,219,220,227)(H4,221,222,228)(H4,223,224,229);(H,6,7)/t110-,111-,112-,113-,114+,126-,127-,128-,129-,130-,131-,132-,133
InChi Key
ZVQNATSHOKCOOH-QVYWEAGBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $369

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    Product Description

    Acetyl pituitary adenylate cyclase-activating peptide (PACAP) (1-38) is an N-terminally acetylated form of PACAP (1-38) (Item No. 24770).1 It binds to the PACAP receptor PAC1 (IC50 = 5.6 nM for the human receptor) and induces calcium mobilization and proliferation of PC12 cells (EC50s = 4.4 and 0.83 nM, respectively) with an efficacy comparable to PACAP (1-38). Acetyl PACAP (1-38) is resistant to degradation by dipeptidyl peptidase 4 (DPP-4) with a 10-fold longer half-life than PACAP (1-38), respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bourgault, S., Vaudry, D., Botia, B., et al. Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides 29(6), 919-932 (2008).