A peptide substrate for CaMK and CaMKII
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Autocamtide 2 (trifluoroacetate salt)

Item No. 24788

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-threonyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine, trifluoroacetate salt
Molecular Formula
C65H118N22O20 • XCF3COOH
Formula Weight
1527.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C65H118N22O20.C2HF3O2/c1-31(2)28-43(83-51(94)34(7)76-54(97)38(17-11-13-25-67)78-53(96)37(68)16-10-12-24-66)60(103)80-40(19-15-27-75-65(72)73)55(98)79-39(18-14-26-74-64(70)71)56(99)81-41(20-22-46(69)89)57(100)82-42(21-23-47(90)91)58(101)87-50(36(9)88)62(105)86-49(33(5)6)61(104)84-44(30-48(92)93)59(102)77-35(8)52(95)85-45(63(106)107)29-32(3)4;3-2(4,5)1(6)7/h31-45,49-50,88H,10-30,66-68H2,1-9H3,(H2,69,89)(H,76,97)(H,77,102)(H,78,96)(H,79,98)(H,80,103)(H,81,99)(H,82,100)(H,83,94)(H,84,104)(H,85,95)(H,86,105)(H,87,101)(H,90,91)(H,92,93)(H,106,107)(H4,70,71,74)(H4,72,73,75);(H,6,7)/t34-,35-,36+,37-,38-,39-,40-,41-,42-,43-,44-,45-,49-,50-;/m0./s1
InChi Key
LLNOFJJCOGGKCB-ZOUHFXOGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $101

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    Product Description

    Autocamtide 2 is a peptide substrate for calcium/calmodulin-dependent protein kinase (CaMK) and CaMKII.1,2 It is selectively phosphorylated by CaMK over bovine brain protein kinase C (PKC; Kms = 2 and >50 μM, respectively).1 Autocamtide 2 phosphorylation can be used to quantify CaMK and CaMKII activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hanson, P.I., Kapiloff, M.S., Lou, L.L., et al. Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation. Neuron 3(1), 59-70 (1989).

    2. Wenham, R.M., Landt, M., and Easom, R.A. Glucose activates the multifunctional Ca2+/calmodulin-dependent protein kinase II in isolated rat pancreatic islets. The Journal of Biological Chemisty 269(7), 4947-4952 (1994).