A fluorogenic substrate for MMP-1, MMP-2, MMP-3, and MMP-9
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Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2, (trifluoroacetate salt)

Item No. 24842

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-[[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]-1-oxobutyl]-L-prolyl-L-glutaminylglycyl-L-leucyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-alanyl-L-lysinamide, trifluoroacetate salt
Synonyms
  • MMP Fluorogenic Substrate III
Molecular Formula
C63H88N16O14S • XCF3COOH
Formula Weight
1325.5
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
CN(C)C1=CC=C(/N=N/C2=CC=C(C(NCCCC(N3[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(NCCNC4=CC=CC5=C4C=CC=C5S(O)(=O)=O)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)C)=O)=O)=O)=O)=O)CCC3)=O)=O)C=C2)C=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C63H88N16O14S.C2HF3O2/c1-38(2)36-50(62(89)74-49(61(88)71-39(3)58(85)73-47(57(66)84)14-6-7-31-64)28-30-54(81)68-34-33-67-46-15-8-13-45-44(46)12-9-17-52(45)94(91,92)93)72-55(82)37-70-60(87)48(27-29-53(65)80)75-63(90)51-16-11-35-79(51)56(83)18-10-32-69-59(86)40-19-21-41(22-20-40)76-77-42-23-25-43(26-24-42)78(4)5;3-2(4,5)1(6)7/h8-9,12-13,15,17,19-26,38-39,47-51,67H,6-7,10-11,14,16,18,27-37,64H2,1-5H3,(H2,65,80)(H2,66,84)(H,68,81)(H,69,86)(H,70,87)(H,71,88)(H,72,82)(H,73,85)(H,74,89)(H,75,90)(H,91,92,93);(H,6,7)/b77-76+;/t39-,47-,48-,49-,50-,51-;/m0./s1
InChi Key
MDFUXCYNTVSLJX-ZGXXBONISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $362

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    Product Description

    Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3, and MMP-9.1 Upon enzymatic cleavage by MMP-1, MMP-2, MMP-3, or MMP-9 at the Gly-Leu site, EDANS is separated from the Dabcyl quencher and its fluorescence can be used to quantify MMP-1, MMP-2, MMP-3, and MMP-9 activity.1,2 EDANS displays excitation/emission maxima of 340/485 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beekman, B., Drijfhout, J.W., Bloemhoff, W., et al. Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media. FEBS Lett. 390(2), 221-225 (1996).

    2. Krismastuti, F.S.H., Pace, S., and Voelcker, N.H. Porous silicon resonant microcavity biosensor for matrix metalloproteinase detection. Adv. Funct. Mater. 24(23), 3639-3650 (2014).