A fluorogenic substrate for MMP-1, MMP-2, and MMP-3
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FITC-C6-PLALWAR-Lys(Biotin)-NH2 (trifluoroacetate salt)

Item No. 24844

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3-(6-((S)-2-(((4S,7S,10S,13S,16S,19S,22S)-13-((1H-indol-3-yl)methyl)-22-carbamoyl-19-(3-guanidinopropyl)-10-isobutyl-2,7,16-trimethyl-5,8,11,14,17,20,28-heptaoxo-32-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12,15,18,21,27-heptaazadotriacontan-4-yl)carbamoyl)pyrrolidin-1-yl)-6-oxohexyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, trifluoroacetate salt
Synonyms
  • FITC-C6-Pro-Leu-Ala-Leu-Trp-Ala-Arg-Lys(Biotin)-NH2
  • MMP-1/MMP-2/MMP-3 Fluorogenic Substrate
Molecular Formula
C83H112N18O16S2 • XCF3COOH
Formula Weight
1682.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](NC([C@H](C)NC([C@@H](NC([C@H]3N(C(CCCCCNC(NC4=CC(C(O)=O)=C(C5=C(C=C6)C(OC7=C5C=CC(O)=C7)=CC6=O)C=C4)=S)=O)CCC3)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)CCCNC(N)=N)=O)CCCCNC(CCCC[C@H]8[C@](NC(N9)=O)([H])[C@]9([H])CS8)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C83H112N18O16S2.C2HF3O2/c1-44(2)36-60(98-79(113)64-22-17-35-101(64)69(105)25-8-7-14-33-89-83(118)93-49-26-29-53(56(39-49)80(114)115)70-54-30-27-50(102)40-65(54)117-66-41-51(103)28-31-55(66)70)76(110)91-47(6)74(108)96-61(37-45(3)4)78(112)97-62(38-48-42-90-57-19-10-9-18-52(48)57)77(111)92-46(5)73(107)95-59(21-16-34-88-81(85)86)75(109)94-58(72(84)106)20-13-15-32-87-68(104)24-12-11-23-67-71-63(43-119-67)99-82(116)100-71;3-2(4,5)1(6)7/h9-10,18-19,26-31,39-42,44-47,58-64,67,71,90,102H,7-8,11-17,20-25,32-38,43H2,1-6H3,(H2,84,106)(H,87,104)(H,91,110)(H,92,111)(H,94,109)(H,95,107)(H,96,108)(H,97,112)(H,98,113)(H,114,115)(H4,85,86,88)(H2,89,93,118)(H2,99,100,116);(H,6,7)/t46-,47-,58-,59-,60-,61-,62-,63-,64-,67-,71-;/m0./s1
InChi Key
NXYLKZUVYMYYGD-XGASVECQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    Product Description

    FITC-C6-PLALWAR-Lys(Biotin)-NH2 is a substrate for matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 that can be sequestered by streptavidin via its biotin group.1 Upon cleavage by MMP-1, MMP-2, or MMP-3, FITC is released and its fluorescence can be used to quantify MMP-1, MMP-2, and MMP-3 activity. FITC displays excitation/emission maxima of 485/535 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobsen, E.J., Mitchell, M.A., Hendges, S.K., et al. Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J. Med. Chem. 42(9), 1525-1536 (1999).