A corticostatic peptide
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Corticostatin (human) (trifluoroacetate salt)

Item No. 24888

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • DEFA4 Protein
  • α-Defensin 4
  • Defensin HNP-4
  • Human Neutrophil Peptide 4
  • Neutrophil Defensin 4
Molecular Formula
C157H255N49O43S6 • XCF3COOH
Formula Weight
3709.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(N)=O)C1=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N2)C3=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CSSC[C@H](N1)C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@H](C2=O)CC5=CC=C(O)C=C5)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N3)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C157H255N49O43S6.C2HF3O2/c1-22-80(18)119-146(242)176-61-110(214)175-62-112(216)199-116(77(12)13)147(243)192-102(65-208)136(232)188-99(58-85-36-27-24-28-37-85)135(231)205-122(83(21)211)151(247)190-98(59-86-43-45-87(212)46-44-86)131(227)194-106-69-253-250-66-103-138(234)181-88(38-29-49-170-153(160)161)123(219)179-91(41-32-52-173-156(166)167)128(224)204-120(81(19)209)150(246)184-93(47-48-113(217)218)125(221)185-94(54-72(2)3)129(225)180-90(40-31-51-172-155(164)165)126(222)200-115(76(10)11)145(241)177-63-111(215)178-100(60-109(158)213)132(228)195-105(140(236)187-96(56-74(6)7)134(230)203-119)68-252-251-67-104(139(235)182-89(39-30-50-171-154(162)163)124(220)186-95(55-73(4)5)133(229)201-117(78(14)15)148(244)189-97(130(226)193-103)57-84-34-25-23-26-35-84)196-137(233)101(64-207)191-141(237)107(198-144(240)114(159)75(8)9)70-254-255-71-108(197-142(106)238)143(239)206-121(82(20)210)149(245)183-92(42-33-53-174-157(168)169)127(223)202-118(79(16)17)152(248)249;3-2(4,5)1(6)7/h23-28,34-37,43-46,72-83,88-108,114-122,207-212H,22,29-33,38-42,47-71,159H2,1-21H3,(H2,158,213)(H,175,214)(H,176,242)(H,177,241)(H,178,215)(H,179,219)(H,180,225)(H,181,234)(H,182,235)(H,183,245)(H,184,246)(H,185,221)(H,186,220)(H,187,236)(H,188,232)(H,189,244)(H,190,247)(H,191,237)(H,192,243)(H,193,226)(H,194,227)(H,195,228)(H,196,233)(H,197,238)(H,198,240)(H,199,216)(H,200,222)(H,201,229)(H,202,223)(H,203,230)(H,204,224)(H,205,231)(H,206,239)(H,217,218)(H,248,249)(H4,160,161,170)(H4,162,163,171)(H4,164,165,172)(H4,166,167,173)(H4,168,169,174);(H,6,7)/t80-,81+,82+,83+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,114-,115-,116-,117-,118-,119-,120-,121-,122-;/m0./s1
InChi Key
AHHNPMUFSIAPIF-UOZSNEBQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Corticostatin is a corticostatic peptide that has been found in human granulocytes.1 It inhibits corticosterone production stimulated by adrenocorticotropic hormone (ACTH) in rat adrenal cells (IC50 = 0.7 μM). Corticostatin also reduces mitogen-stimulated release of IFN-γ and IL-6 in human peripheral blood mononuclear cells (PBMCs).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, A., Bateman, A., Zhu, Q., et al. Structure of a novel human granulocyte peptide with anti-ACTH activity. Biochem. Biophys. Res. Commun. 155(1), 524-529 (1988).

    2. Masera, R.G., Bateman, A., Muscettola, M., et al. Corticostatins/defensins inhibit in vitro NK activity and cytokine production by human peripheral blood mononuclear cells. Regul. Pept. 62(1), 13-21 (1996).