A peptide fragment of amylin
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Amylin (8-37) (human) (trifluoroacetate salt)

Item No. 24894

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosine, trifluoroacetate salt
Synonyms
  • IAPP (8-37) (human)
  • Islet Amyloid Polypeptide (8-37) (human)
Molecular Formula
C138H215N41O46 • XCF3COOH
Formula Weight
3184.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)C)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C138H215N41O46.C2HF3O2/c1-19-65(12)106(133(220)166-80(40-61(4)5)117(204)170-93(56-182)129(216)173-95(58-184)130(217)179-108(70(17)186)135(222)168-89(50-101(145)194)124(211)174-104(63(8)9)131(218)151-53-103(196)155-91(54-180)126(213)165-88(49-100(144)193)125(212)178-109(71(18)187)136(223)169-90(137(224)225)44-74-32-34-76(188)35-33-74)176-112(199)67(14)153-102(195)52-150-113(200)82(42-72-27-22-20-23-28-72)161-121(208)86(47-98(142)191)163-122(209)87(48-99(143)192)164-127(214)92(55-181)172-128(215)94(57-183)171-119(206)84(45-75-51-148-59-152-75)167-132(219)105(64(10)11)175-123(210)81(41-62(6)7)160-118(205)83(43-73-29-24-21-25-30-73)162-120(207)85(46-97(141)190)158-111(198)68(15)154-116(203)79(39-60(2)3)159-114(201)77(31-26-38-149-138(146)147)156-115(202)78(36-37-96(140)189)157-134(221)107(69(16)185)177-110(197)66(13)139;3-2(4,5)1(6)7/h20-25,27-30,32-35,51,59-71,77-95,104-109,180-188H,19,26,31,36-50,52-58,139H2,1-18H3,(H2,140,189)(H2,141,190)(H2,142,191)(H2,143,192)(H2,144,193)(H2,145,194)(H,148,152)(H,150,200)(H,151,218)(H,153,195)(H,154,203)(H,155,196)(H,156,202)(H,157,221)(H,158,198)(H,159,201)(H,160,205)(H,161,208)(H,162,207)(H,163,209)(H,164,214)(H,165,213)(H,166,220)(H,167,219)(H,168,222)(H,169,223)(H,170,204)(H,171,206)(H,172,215)(H,173,216)(H,174,211)(H,175,210)(H,176,199)(H,177,197)(H,178,212)(H,179,217)(H,224,225)(H4,146,147,149);(H,6,7)/t65-,66-,67-,68-,69+,70+,71+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,104-,105-,106-,107-,108-,109-;/m0./s1
InChi Key
LEJOSZKCTLTERK-OJNSZWJJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Amylin (8-37) is a peptide fragment of amylin (Item Nos. 24274 | 24275).1 It inhibits osteoblast proliferation, but not bone resorption, induced by full-length human amylin and does not act as an agonist at amylin receptors. Amylin (8-37) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures.2 It is cytotoxic to RINm5F islet β-cells in vitro when used at a concentration of 25 µM, an effect that is inversely correlated with mature fibril content.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cornish, J., Callon, K.E., Lin, C.Q., et al. Dissociation of the effects of amylin on osteoblast proliferation and bone resorption. Am. J. Physiol. 274(5 Pt 1), E827-833 (1998).

    2. Goldsbury, C., Goldie, K., Pellaud, J., et al. Amyloid fibril formation from full-length and fragments of amylin. J. Struct. Biol. 130(2-3), 352-362 (2000).

    3. Konarkowska, B., Aitken, J.F., Kistler, J., et al. The aggregation potential of human amylin determines its cytotoxicity towards islet β-cells. FEBS J. 273(15), 3614-3624 (2006).