An inhibitor of PLA2
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Folipastatin

Item No. 24924

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,8-dihydroxy-4,9-dimethyl-1,6-bis[(1Z)-1-methyl-1-propen-1-yl]-11H-dibenzo[b,e][1,4]dioxepin-11-one
CAS Number
139959-71-0
Molecular Formula
C23H24O5
Formula Weight
380.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC1=C2C(OC(C(C)=C(O)C=C3/C(C)=C/C)=C3C(O2)=O)=C(/C(C)=C\C)C=C1O
InChi Code
InChI=1S/C23H24O5/c1-7-11(3)15-9-17(24)13(5)20-19(15)23(26)28-21-14(6)18(25)10-16(12(4)8-2)22(21)27-20/h7-10,24-25H,1-6H3/b11-7+,12-8-
InChi Key
JJMKBGPTPXPMBH-RLCSYUECSA-N
Origin
Fungus/Aspergillus unguis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $174

    Add

    2.5 mg

    $648

    Add
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    Product Description

    Folipastatin is a fungal metabolite produced by A. unguis and an inhibitor of phospholipase A2 (PLA2; IC50 = 39 μM).1 It inhibits release of arachidonic acid (Item Nos. 90010 | 10006607) from rat polymorphonuclear leukocytes (IC50 = 24 μM). Folipistatin also inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50 = 0.39 μM) but has no effect on contraction of taenia (IC50 = >100 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamano, K., Kinoshita-Okami, M., Hemmi, A., et al. Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties. J. Antibiot. (Tokyo) 45(8), 1195-1201 (1992).