An iridoid glycoside
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Product Categories

Product Type

Biochemicals
Natural Products
Glycosides

Research Area

Neuroscience

Catalpol

Item No. 24925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1aS,1bS,2S,5aR,6S,6aS-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, β-D-glucopyranoside
CAS Number
2415-24-9
Synonyms
  • Catalpinoside
  • 7,8-epoxy Aucubin
Molecular Formula
C15H22O10
Formula Weight
362.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@H]2[C@@]([C@@](CO)(O3)[C@@H]3[C@H]4O)([H])[C@@]4([H])C=CO2)([H])O1
InChi Code
InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/m1/s1
InChi Key
LHDWRKICQLTVDL-PZYDOOQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $66

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    100 mg

    $117

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    250 mg

    $222

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    1 g

    $630

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    Product Description

    Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties.1 It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 µM.2,3 Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 µg/ml and 25 to 100 mg/kg, respectively.4 In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Liao, D., Qin, M., et al. Simultaneous determination of catalpol, aucubin, and geniposidic acid in different developmental stages of Rehmannia glutinosa leaves by high performance liquid chromatography. J. Anal. Methods Chem. 2016:4956589, (2016).

    2. Chen, W., Li, X., Jia, L.-Q., et al. Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells. Br. J. Pharmacol. 169(5), 1140-1152 (2013).

    3. Hu, L.-a., Sun, Y.-k., Zhang, H.-s., et al. Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway. Biosci. Rep. 36(3), e00348 (2016).

    4. Chen, C., Chen, Z., Xu, F., et al. Radio-protective effect of catalpol in cultured cells and mice. J. Radiat. Res. 54(1), 76-82 (2013).

    5. Zhu, H.-F., Wan, D., Luo, Y., et al. Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion. Int. J. Biol. Sci. 6(5), 443-453 (2010).