A fluorogenic substrate of heparin sulphamidase
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4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)

Item No. 24931

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[2-deoxy-2-(sulfoamino)-α-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one, monosodium salt
CAS Number
460085-45-4
Synonyms
  • 4-MU-α-GlcNS
Molecular Formula
C16H18NO10S • Na
Formula Weight
439.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleWater: Slightly Soluble
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](NS([O-])(=O)=O)[C@@H](OC2=CC=C(C(C)=CC(O3)=O)C3=C2)O1.[Na+]
InChi Code
InChI=1S/C16H19NO10S.Na/c1-7-4-12(19)26-10-5-8(2-3-9(7)10)25-16-13(17-28(22,23)24)15(21)14(20)11(6-18)27-16;/h2-5,11,13-18,20-21H,6H2,1H3,(H,22,23,24);/q;+1/p-1/t11-,13-,14-,15-,16+;/m1./s1
InChi Key
LMECUNAMBHBGFU-MYDYNYEJSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase.1 Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm.1,2 The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.2 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karpova, E.A., Voznyi, Y.V., Keulemans, J.L.M., et al. A fluorimetric enzyme assay for the diagnosis of Sanfilippo disease type A (MPS IIIA). J. Inherit. Metab. Dis. 19(3), 278-285 (1996).

    2. Zhi, H., Wang, J., Wang, S., et al. Fluorescent properties of hymecromone and fluorimetric analysis of hymecromone in compound dantong capsule. J. Spectrosc. 147128 (2013).

    3. Civallero, G., De Mari, J., Viapiana Camelier, M., et al. Assay of heparan-N-sulfamidase in dried leukocytes impregnated in filter paper: A new tool for the identification of mucopolisaccharidosis IIIA and potentially other lysosomal disorders. Mol. Genet. Metab. 108(4), 267-268 (2013).