An inhibitor of BACE1 and BACE2
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AZD 3293

Item No. 24934

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,1′R,4β)-4-methoxy-5′′-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-dispiro[cyclohexane-1,2′-[2H]indene-1′(3′H),2′′-[2H]imidazol]-4′′-amine
CAS Number
1383982-64-6
Synonyms
  • Lanabecestat
  • LY3314814
Molecular Formula
C26H28N4O
Formula Weight
412.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
241 nm
SMILES
CO[C@@H](CC1)CC[C@@]1(C2)[C@]3(N=C(C)C(N)=N3)C4=C2C=CC(C5=CC(C#CC)=CN=C5)=C4
InChi Code
InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25-,26-/m0/s1
InChi Key
WKDNQONLGXOZRG-HRNNMHKYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $318

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    10 mg

    $493

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    Product Description

    AZD 3293 is an inhibitor of β-secretase 1 (BACE1) and BACE2 (Kis = 0.4 and 0.8 nM, respectively).1 It is selective for BACE1 and BACE2 over cathepsin D, γ-secretase, and human-ether-a-go-go (hERG; IC50s = 3,797, >25,000, and 4,700 nM, respectively). AZD 3293 inhibits the secretion of amyloid-β (1-40) (Aβ40) in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human amyloid precursor protein (APP; IC50 = 0.08 nM). In vivo, AZD 3293 (50, 100, and 200 µmol/kg) reduces plasma and brain levels of Aβ40 and brain levels of Aβ42 in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eketjäll, S., Janson, J., Kaspersson, K., et al. AZD3293: A novel, orally active BACE1 inhibitor with high potency and permeability and markedly slow off-rate kinetics. J. Alzheimers Dis. 50(4), 1109-1123 (2016).