An inhibitor of BACE1 and BACE2
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AZD 3293

Item No. 24934

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,1′R,4β)-4-methoxy-5′′-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-dispiro[cyclohexane-1,2′-[2H]indene-1′(3′H),2′′-[2H]imidazol]-4′′-amine
CAS Number
1383982-64-6
Synonyms
  • Lanabecestat
  • LY3314814
Molecular Formula
C26H28N4O
Formula Weight
412.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
241 nm
SMILES
CO[C@@H](CC1)CC[C@@]1(C2)[C@]3(N=C(C)C(N)=N3)C4=C2C=CC(C5=CC(C#CC)=CN=C5)=C4
InChi Code
InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25-,26-/m0/s1
InChi Key
WKDNQONLGXOZRG-HRNNMHKYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $72

    Add

    5 mg

    $318

    Add

    10 mg

    $493

    Add
    Product Description

    AZD 3293 is an inhibitor of β-secretase 1 (BACE1) and BACE2 (Kis = 0.4 and 0.8 nM, respectively).1 It is selective for BACE1 and BACE2 over cathepsin D, γ-secretase, and human-ether-a-go-go (hERG; IC50s = 3,797, >25,000, and 4,700 nM, respectively). AZD 3293 inhibits the secretion of amyloid-β (1-40) (Aβ40) in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human amyloid precursor protein (APP; IC50 = 0.08 nM). In vivo, AZD 3293 (50, 100, and 200 µmol/kg) reduces plasma and brain levels of Aβ40 and brain levels of Aβ42 in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eketjäll, S., Janson, J., Kaspersson, K., et al. AZD3293: A novel, orally active BACE1 inhibitor with high potency and permeability and markedly slow off-rate kinetics. J. Alzheimers Dis. 50(4), 1109-1123 (2016).