An endogenous opioid peptide
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α-Endorphin (human, mouse, rat, porcine, bovine, ovine)

Item No. 24958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-α-glutamyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonine
CAS Number
59004-96-5
Molecular Formula
C77H120N18O26S
Formula Weight
1746.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=C(O)C=C3
InChi Code
InChI=1S/C77H120N18O26S/c1-38(2)31-51(70(113)91-60(39(3)4)74(117)94-63(42(7)100)77(120)121)88-73(116)55-18-14-29-95(55)76(119)62(41(6)99)93-67(110)48(23-25-56(80)102)85-71(114)53(36-96)89-65(108)47(17-12-13-28-78)84-66(109)49(24-26-59(105)106)86-72(115)54(37-97)90-75(118)61(40(5)98)92-68(111)50(27-30-122-8)87-69(112)52(33-43-15-10-9-11-16-43)83-58(104)35-81-57(103)34-82-64(107)46(79)32-44-19-21-45(101)22-20-44/h9-11,15-16,19-22,38-42,46-55,60-63,96-101H,12-14,17-18,23-37,78-79H2,1-8H3,(H2,80,102)(H,81,103)(H,82,107)(H,83,104)(H,84,109)(H,85,114)(H,86,115)(H,87,112)(H,88,116)(H,89,108)(H,90,118)(H,91,113)(H,92,111)(H,93,110)(H,94,117)(H,105,106)(H,120,121)/t40-,41-,42-,46+,47+,48+,49+,50+,51+,52+,53+,54+,55+,60+,61+,62+,63+/m1/s1
InChi Key
NXSIJWJXMWBCBX-NWKQFZAZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    α-Endorphin is an endogenous neuropeptide that binds to opioid receptors in guinea pig brain membranes (IC50 = 97 nM).1 It induces chemotaxis of human monocytes in vitro when used at a concentration of 0.1 nM and inhibits electrically-induced contractions in guinea pig ileum and mouse vas deferens (IC50s = 325 and 27.6 nM, respectively).2,1 In vivo, α-endorphin delays extinction of pole-jumping avoidance behavior in rats (ED50s = 40 and 2 pM, respectively, for s.c. and i.c.v. administration).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Waterfield, A.A., Leslie, F.M., Lord, J.A., et al. Opioid activities of fragments of β-endorphin and of its leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin. Eur. J. Pharmacol. 58(1), 11-18 (1979).

    2. Sacerdote, P., and Panerai, A.E. Analysis of the beta-endorphin structure-related activity on human monocyte chemotaxis: Importance of the N- and C-terminal. Peptides 10(3), 565-569 (1989).

    3. de Wied, D., Bohus, B., van Ree, J.M., et al. Behavioral and electrophysiological effects of peptides related to lipotropin (β-LPH). J. Pharmacol. Exp. Ther. 204(3), 570-580 (1978).