A cyclotetrapeptide fungal metabolite
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Hirsutide

Item No. 25014

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo(N-methyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-valyl)
CAS Number
865368-30-5
Molecular Formula
C34H40N4O4
Formula Weight
568.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)N(C)C([C@H](C(C)C)N3)=O)=O)N(C)[C@@H](CC4=CC=CC=C4)C3=O
InChi Code
InChI=1S/C34H40N4O4/c1-23(2)30-34(42)38(4)28(21-25-16-10-6-11-17-25)31(39)35-27(20-24-14-8-5-9-15-24)33(41)37(3)29(32(40)36-30)22-26-18-12-7-13-19-26/h5-19,23,27-30H,20-22H2,1-4H3,(H,35,39)(H,36,40)/t27-,28-,29-,30-/m0/s1
InChi Key
YJRWOFGXVILYEW-KRCBVYEFSA-N
Origin
Fungus/Aspergillus sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella.1 It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively).2 Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lang, G., Blunt, J.W., Cummings, N.J., et al. Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp. J. Nat. Prod. 68(8), 1303-1305 (2005).

    2. Dahiya, R., Kumar, A., and Maheshwari, M. Toward the synthesis and biological evaluation of hirsutide. Montash. Chem. 140(1), 121-127 (2009).