An inhibitor of IDO1
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BMS 986205

Item No. 25025

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cis-(αR)-N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-α-methyl-cyclohexaneacetamide
CAS Number
1923833-60-6
Synonyms
  • Linrodostat
Molecular Formula
C24H24ClFN2O
Formula Weight
410.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 90 mg/ml
λmax
218, 251 nm
SMILES
FC1=CC2=C(C=C1)N=CC=C2[C@@H]3CC[C@@]([C@@H](C)C(NC4=CC=C(Cl)C=C4)=O)([H])CC3
InChi Code
InChI=1S/C24H24ClFN2O/c1-15(24(29)28-20-9-6-18(25)7-10-20)16-2-4-17(5-3-16)21-12-13-27-23-11-8-19(26)14-22(21)23/h6-17H,2-5H2,1H3,(H,28,29)/t15-,16-,17+/m1/s1
InChi Key
KRTIYQIPSAGSBP-ZACQAIPSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $402

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    25 mg

    $801

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    Cayman Chemical
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    Product Description

    BMS 986205 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IC50 = <50 nM).1 It inhibits kynurenine synthesis in HeLa cells and IDO1-overexpressing HEK293 cells (IC50s = 1.1 and 1.7 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheong, J.E., Ekkati, A., and Sun, L. A patent review of IDO1 inhibitors for cancer. Exp. Opin. Ther. Pat. 28(4), 317-330 (2018).