An internal standard for the quantification of cinacalcet
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Unlabeled Version(s)
16042Cinacalcet (hydrochloride)
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Cinacalcet-d3 (hydrochloride)

Item No. 25036

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR)-α-(methyl-d3)-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride
CAS Number
2749807-20-1
Synonyms
  • AMG 073-d3
Molecular Formula
C22H19D3F3N • HCl
Formula Weight
396.9
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
[2H]C([2H])([2H])[C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1/i1D3;
InChi Key
QANQWUQOEJZMLL-GFGUQVGFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $108

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    1 mg

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    Product Description

    Cinacalcet-d3 is intended for use as an internal standard for the quantification of cinacalcet (Item No. 16042) by GC- or LC-MS. Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).1 In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.2 Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, J.N., Owens, M., Gustafsson, M., et al. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J. Pharmacol. Exp. Ther. 337(1), 275-284 (2011).

    2. Imanishi, Y., Kawata, T., Kenko, T., et al. Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism. Calcif. Tissue Int. 89(1), 29-35 (2011).