An active metabolite of aconitine
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Aconine

Item No. 25048

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol
CAS Number
509-20-6
Molecular Formula
C25H41NO9
Formula Weight
499.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CO[C@@H]1C2(C3N4CC)[C@@]([C@@H](OC)C3[C@]([C@@H](O)[C@H](OC)[C@]5(O)[C@@H]6O)(O)[C@]6([H])[C@]2(C5)[H])([H])[C@](COC)(C4)[C@H](O)C1
InChi Code
InChI=1S/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12-,13+,14-,15?,16+,17-,18?,19-,20+,21+,22+,23-,24?,25-/m1/s1
InChi Key
SQMGCPHFHQGPIF-FGBFNOOXSA-N
Origin
Plant/Aconitum carmichaelii Debx
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

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    10 mg

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    Product Description

    Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine.1 It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner.2 Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg.1 It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wada, K., Nihira, M., and Ohno, Y. Effects of chronic administrations of aconitine on body weight and rectal temperature in mice. J. Ethnopharmacol. 105(1-2), 89-94 (2006).

    2. Zeng, X.-Z., He, L.-G., Wang, S., et al. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression. Acta Pharmacol. Sin. 37(2), 255-263 (2016).

    3. Li, T.-F., Gong, N., and Wang, Y.-X. Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: Involvement of spinal microglial dynorphin expression and implications for aconitum processing. Front. Pharmacol. 7:367, (2016).