A diterpene tanshinone with diverse biological activities
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15,16-Dihydrotanshinone I

Item No. 25051

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R)-1,2-dihydro-1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione
CAS Number
87205-99-0
Synonyms
  • DHTS
  • Dihydrotanshinone I
Molecular Formula
C18H14O3
Formula Weight
278.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.2 mg/mlDMSO: 0.2 mg/ml
λmax
215, 241, 290 nm
SMILES
O=C(C1=C2C(C(C)=CC=C2)=CC=C1C3=C4[C@@H](C)CO3)C4=O
InChi Code
InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChi Key
HARGZZNYNSYSGJ-JTQLQIEISA-N
Origin
Plant/Salvia miltiorrhiza
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $169

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    25 mg

    $359

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    50 mg

    $477

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    Product Description

    15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.1 DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.2 It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.1 DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM).3 In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.4 In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 μM).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. D'Agostino, V.G., Lal, P., Mantelli, B., et al. Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function. Sci. Rep. 5:16478, (2015).

    2. Choi, H.S., and Kim, K.M. Tanshinones inhibit mast cell degranulation by interfering with IgE receptor-mediated tyrosine phosphorylation of PLCγ2 and MAPK. Planta Med. 70(2), 178-180 (2004).

    3. Park, J.W., Lee, S.H., Yang, M.K., et al. 15,16-Dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch. Pharm. Res. 31(1), 47-53 (2008).

    4. Liu, J.J., Wu, H.H., Chen, T.H., et al. 15,16-Dihydrotanshinone I from the functional food Salvia miltiorrhiza exhibits anticancer activity in human HL-60 leukemia cells: In vitro and in vivo studies. Int. J. Mol. Sci. 16(8), 19387-19400 (2015).

    5. Kim, D.H., Jeon, S.J., Jung, J.W., et al. Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Eur. J. Pharmacol. 574(2-3), 140-147 (2007).