An alkaloid with diverse biological activities
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Dehydroevodiamine (hydrochloride)

Item No. 25101

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,14-dihydro-14-methyl-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, monohydrochloride
CAS Number
111664-82-5
Molecular Formula
C19H15N3O • HCl
Formula Weight
337.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 12.5 mg/mlEthanol: 2.5 mg/ml
λmax
248, 315, 367 nm
SMILES
CN(C1=CC=CC=C1C(N2CC3)=O)C2=C4C3=C(C=CC=C5)C5=N4.Cl
InChi Code
InChI=1S/C19H15N3O.ClH/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22;/h2-9H,10-11H2,1H3;1H
InChi Key
SVOMSEHNGXLQRU-UHFFFAOYSA-N
Origin
Plant/Euodiae fructus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    50 mg

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    100 mg

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    250 mg

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    Cayman Chemical
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    Product Description

    Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.1,2,3,4 It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.1 Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.2 In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.3 Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Noh, E.J., Ahn, K.S., Shin, E.M., et al. Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-κB activation in RAW 264.7 macrophages. Life Sci. 79(7), 695-701 (2006).

    2. Loh, S.-H., Tsai, Y.-T., Lee, C.-Y., et al. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes. J. Ethnopharmacol. 153(3), 753-762 (2014).

    3. Yang, M.C.M., Wu, S.-L., Kuo, J.-S., et al. The hypotensive and negative chronotropic effects of dehydroevodiamine. Eur. J. Pharmacol. 182(3), 537-542 (1990).

    4. Wang, H.-H., Chou, C.-J., Liao, J.-F., et al. Dehydroevodiamine attenuates β-amyloid peptide-induced amnesia in mice. Eur. J. Pharmacol. 413(2-3), 221-225 (2001).