A triterpene glycoside
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23-epi-26-Deoxyactein

Item No. 25126

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,12β,16β,23S,24R,25R)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl, β-D-xylopyranoside
CAS Number
264624-38-6
Synonyms
  • 27-Deoxyactein
Molecular Formula
C37H56O10
Formula Weight
660.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
C[C@](CO1)(O2)[C@@H]2[C@@]31O[C@@]4([H])C[C@@]5(C)[C@]6([H])CC[C@]7([H])[C@]8(CC[C@H](O[C@]9([H])OC[C@@H](O)[C@H](O)[C@H]9O)C7(C)C)[C@]6(C8)C[C@@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](C)C3
InChi Code
InChI=1S/C37H56O10/c1-18-12-37(30-33(6,47-30)17-43-37)46-21-13-32(5)23-9-8-22-31(3,4)24(45-29-28(41)27(40)20(39)15-42-29)10-11-35(22)16-36(23,35)14-25(44-19(2)38)34(32,7)26(18)21/h18,20-30,39-41H,8-17H2,1-7H3/t18-,20-,21+,22+,23+,24+,25-,26+,27+,28-,29+,30-,32+,33-,34-,35-,36+,37+/m1/s1
InChi Key
GCMGJWLOGKSUGX-RBKCHLQLSA-N
Origin
Plant/Cimicifugae rhizoma
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

    $75

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    5 mg

    $255

    Add
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    Product Description

    23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa).1,2 It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).1 23-epi-26-Deoxyactein (0.01-10 μM) reduces production of ROS and IL-1β and cell death induced by methylglyoxal in RIN-m5F β-cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suh, K.S., Choi, E.M., Jung, W.-W., et al. 27-Deoxyactein prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cellular damage in MC3T3-E1 osteoblastic cells. J. Environ. Sci. Health A. Tox. Hazard Subst. Environ. Eng. 53(6), 561-570 (2018).

    2. Suh, K.S., Choi, E.M., Jung, W.-W., et al. Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis. Int. J. Mol. Med. 40(2), 539-548 (2017).