A lignan with hepatoprotective activity
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Schisandrol B

Item No. 25149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6S,7S,13aR)-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol
CAS Number
58546-54-6
Synonyms
  • Besigomsin
  • Gomisin A
  • Wuweizichun B
Molecular Formula
C23H28O7
Formula Weight
416.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mLEthanol: 5 mg/mL
λmax
219 nm
SMILES
COC1=C(OCO2)C2=CC3=C1C4=C(C=C(OC)C(OC)=C4OC)CC(O)(C)C(C)C3
InChi Code
InChI=1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3
InChi Key
ZWRRJEICIPUPHZ-UHFFFAOYSA-N
Origin
Plant/Schisandra chinensis (Turcz.) Baill.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.1 It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.2 It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Taqguchi, H., and Ikeya, Y. The constituents of Schizandra chinensis BAILL. I. The structures of gomisin A, B and C. Chem. Pharm. Bull. 23(12), 3296-3298 (1975).

    2. Zeng, H., Jiang, Y., Chen, P., et al. Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br. J. Pharmacol. 174(8), 672-688 (2017).

    3. Li, X., Sun, J., Fan, X., et al. Schisandrol B promotes liver regeneration after partial hepatectomy in mice. Eur. J. Pharmacol. 818, 96-102 (2018).

    4. Jiang, Y.-m., Wang, Y., Tan, H.-s., et al. Schisandrol B protects against acetaminopheninduced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway. Acta Pharmacol. Sin. 37(3), 382-389 (2016).