A fluorescent probe for mitochondrial superoxide production
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MitoROS™ 580

Item No. 25169

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Emission
580 nm
Excitation
510 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    MitoROS™ 580 is a fluorescent probe for superoxide production in mitochondria of live cells. It is cell-permeable and targets mitochondria where it is oxidized by superoxide over other reactive oxygen species (ROS) or reactive nitrogen species (RNS). Upon oxidation by superoxide, MitoROS™ 580 fluoresces, and this fluorescence can be measured using fluorescence microscopy or flow cytometry. MitoROS™ 580 displays excitation/emission maxima of 510/580 nm, respectively. MitoROS™ 580 has been used to determine effects of curcumin (Item No. 81025) treatment on superoxide production in Jurkat cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luo, Z., Zhao, Q., Liu, J., et al. 222 - Flow cytometric analysis of intracellular ROS and RNS production and curcumin inhibition. Free Rad. Biol. Med. 100, S103-S104 (2016).