Nodakenin

Nodakenin is a coumarin glucoside originally isolated from P. decursivum that has anti-inflammatory, neuroprotective, and neurogenic activities.^1,2,3,4,5 It dose-dependently reduces LPS-induced increases in TNF-α, IL-6, and IL-1β mRNA expression and protein levels and NK-κB activity and translocation in RAW 264.7 macrophages when used at concentrations ranging from 25 to 100 µM.² Nodakenin (5, 10, and 20 mg/kg) prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of chronic asthma induced by ovalbumin.³ It also decreases the levels of IL-4, IL-5, IL-13, as well as matrix metalloproteinase-2 (MMP-2) and MMP-9 in bronchoalveolar lavage fluid (BALF). Nodakenin increases proliferation of neural progenitor cells in the adult mouse hippocampal dentate gyrus, increases hippocampal protein levels of AKT and glycogen synthase kinase-3β (GSK-3β), and improves learning and memory in the passive avoidance test.⁵

WARNING This product is not for human or veterinary use.

1. Junzo, A. The constitution of nodakenin, a new glucoside from Peucedanum decursivum Maxim. Bull. Chem. Soc. Jpn. 4(1), 16-20 (1929).

2. Rim, H.K., Cho, W., Sung, S.H., et al. Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock. J. Pharmacol. Exp. Ther. 342(3), 654-664 (2012).

3. Xiong, Y., Wang, J., Yu, H., et al. The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacol. Immunotoxicol. 36(5), 341-348 (2014).

4. Kang, S.Y., and Kim, Y.C. Neuroprotective coumarins from the root of Angelica gigas: Structure-activity relationships. Arch. Pharm. Res. 30(11), 1368-1373 (2007).

5. Gao, Q., Jeon, S.J., Jung, H.A., et al. Nodakenin enhances cognitive function and adult hippocampal neurogenesis in mice. Neurochem. Res. 40(7), 1438-1447 (2015).