A water-soluble vitamin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Thiamine (nitrate)

Item No. 25332

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazolium, mononitrate
CAS Number
532-43-4
Synonyms
  • Aneurine
  • Vitamin B1
Molecular Formula
C12H17N4OS • NO3
Formula Weight
327.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
λmax
234, 267, 332 nm
SMILES
CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.[O-][N+]([O-])=O
InChi Code
InChI=1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1
InChi Key
UIERGBJEBXXIGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 g

    $36

    Add

    25 g

    $70

    Add

    50 g

    $110

    Add

    100 g

    $153

    Add
    Product Description

    Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties.1,2,3,4 It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid (Item No. 90260) in vitro when used at concentrations ranging from 1 to 100 μM.1 In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication.2 It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice.3 Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lukienko, P.I., Mel'nichenko, N.G., Zverinskii, I.V., et al. Antioxidant properties of thiamine. Bull. Exp. Biol. Med. 130(9), 874-876 (2000).

    2. Portari, G.V., Ovidio, P.P., Deminice, R., et al. Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication. Life Sci. 162, 21-24 (2016).

    3. Vignisse, J., Sambon, M., Gorlova, A., et al. Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Mol. Cell. Neurosci. 82, 126-136 (2017).

    4. Suzuki, K., Yamada, K., Fukuhara, Y., et al. High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice. PloS One 12(6), e0180279 (2017).