A peptide PPR agonist
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DPC-AJ1951 (trifluoroacetate salt)

Item No. 25343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methylalanyl-L-valyl-2-methylalanyl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-norleucyl-L-histidyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-L-tyrosinamide, trifluoroacetate salt
Molecular Formula
C76H127N23O19 • XCF3COOH
Formula Weight
1667.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleWater: Slightly Soluble
SMILES
O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)[C@@H](NC([C@H](CCCC)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC(C(C)(C)NC([C@H](C(C)C)NC(C(C)(N)C)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C76H127N23O19.C2HF3O2/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43;3-2(4,5)1(6)7/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85);(H,6,7)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-;/m0./s1
InChi Key
YKUXUECHJLLJKO-DCZFVRCFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR).1 It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants. In vivo, DPC-AJ1951 normalizes serum calcium levels in thyroidparathyroidectomized rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carter, P.H., Liu, R.-Q., Foster, W.R., et al. Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe. Proc. Natl. Acad. Sci. USA 104(16), 6846-6851 (2007).