An inhibitor of lysosomal acid lipase
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Lalistat 2

Item No. 25347

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-piperidinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester
CAS Number
1234569-09-5
Molecular Formula
C13H20N4O2S
Formula Weight
296.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
λmax
306 nm
SMILES
O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
InChi Code
InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2
InChi Key
PNYYVHOTXOEBEV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $94

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    10 mg

    $179

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    50 mg

    $609

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    100 mg

    $1,029

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    Product Description

    Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).1 It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosenbaum, A.I., Cosner, C.C., Mariani, C.J., et al. Thiadiazole carbamates: Potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J. Med. Chem. 53(14), 5281-5289 (2010).

    2. Lim, H., Lim, Y.-M., Kim, K.H., et al. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat. Commun. 9:1438, (2018).