A fluorescently tagged sphingolipid
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NBD Sphingosine

Item No. 25348

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3R,4E)-2-amino-18-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-4-octadecene-1,3-diol
CAS Number
1449370-25-5
Molecular Formula
C24H39N5O5
Formula Weight
477.6
Purity
≥95%
Formulation (Request formulation change)
A 250 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
SMILES
OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C12
InChi Code
InChI=1S/C24H39N5O5/c25-19(18-30)22(31)14-12-10-8-6-4-2-1-3-5-7-9-11-13-17-26-20-15-16-21(29(32)33)24-23(20)27-34-28-24/h12,14-16,19,22,26,30-31H,1-11,13,17-18,25H2/b14-12+/t19-,22+/m0/s1
InChi Key
MNFOPKRTMFDMJV-HCEDEFRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $267

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    250 µg

    $865

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    Product Description

    NBD sphingosine is a biologically active derivative of sphingosine (Item No. 10007907) that is tagged with a fluorescent nitrobenzoxadiazole (NBD) group. It has been used to study the cellular localization and metabolism of sphingosine in HeLa cells.1 NBD sphingosine inhibits proliferation of HCT116, PC3, HEK293T, and HFE-145 cells (IC50s = 25.6, 40.5, 10.4, and 12.5 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, Y.M., Lim, C., Lee, H.S., et al. Synthesis and biological evaluation of a polyyne-containing sphingoid base probe as a chemical tool. Bioconjug. Chem. 24(8), 1324-1331 (2013).