An internal standard for the quantification of anastrozole
Related Products
Unlabeled Version(s)
11987Anastrozole
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Anastrozole-d12

Item No. 25360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,α,α',α'-tetra(methyl-d3)-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
CAS Number
120512-32-5
Synonyms
  • Anastrol-d12
Molecular Formula
C17H7D12N5
Formula Weight
305.4
Purity
≥99% deuterated forms (d1-d12)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C#N)C1=CC(C(C([2H])([2H])[2H])(C#N)C([2H])([2H])[2H])=CC(CN2C=NC=N2)=C1
InChi Code
InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3/i1D3,2D3,3D3,4D3
InChi Key
YBBLVLTVTVSKRW-MGKWXGLJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $236

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Anastrozole-d12 is intended for use as an internal standard for the quantification of anastrozole (Item No. 11987) by GC- or LC-MS. Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1).1 It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats.2 It inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys when administered at doses greater than 0.1 mg/kg. Anastrozole (0.5 mg/kg) reduces tumor incidence and the number of tumors by 40 and 57%, respectively, as well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis.3 Formulations containing anastrozole have been used in the treatment of breast cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grimm, S.W., and Dyroff, M.C. Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase. Drug Metab. Dispos. 25(5), 598-602 (1997).

    2. Plourde, P.V., Dyroff, M.C., and Dukes, M. Arimidex®: A potent and selective fourth-generation aromatase inhibitor. Breast Cancer Res. Treat. 30(1), 103-111 (1994).

    3. Kubatka, P., Sadlonová, V., Kajo, K., et al. Chemopreventive effects of anastrozole in a premenopausal breast cancer model. Anticancer Res. 28(5A), 2819-2823 (2008).