An affinity probe for protein lysine crotonylation
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TCEP-biotin

Item No. 25365

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-carboxyethyl)-22-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-7,18-dioxo-11,14-dioxa-8,17-diaza-4-phosphadocosanoic acid
CAS Number
2227020-26-8
Synonyms
  • Tris(2-carboxyethyl)phosphine-biotin
Molecular Formula
C25H43N4O9PS
Formula Weight
606.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 0.15 mg/ml
SMILES
OC(CCP(CCC(NCCOCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)CCC(O)=O)=O
InChi Code
InChI=1S/C25H43N4O9PS/c30-20(4-2-1-3-19-24-18(17-40-19)28-25(36)29-24)26-8-10-37-12-13-38-11-9-27-21(31)5-14-39(15-6-22(32)33)16-7-23(34)35/h18-19,24H,1-17H2,(H,26,30)(H,27,31)(H,32,33)(H,34,35)(H2,28,29,36)/t18-,19-,24-/m0/s1
InChi Key
PMEDGEBIWBYIRE-JXQFQVJHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $290

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    1 mg

    $519

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    Product Description

    TCEP-biotin is biotinylated form of the reducing agent TCEP (Item No. 14329) and an affinity probe for protein lysine crotonylation.1 Covalent addition of the TCEP moiety to crotonylated lysine residues results in adduct formation that allows for detection or immobilization of crotonylated proteins through interaction with the biotin ligand. It has been used in the detection and isolation of crotonylated histones in HEK293 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bos, J., and Muir, T.W. A chemical probe for protein crotonylation. J. Am. Chem. Soc. 140(14), 4757-1760 (2018).