An inhibitor of T-type calcium channels
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ACT-709478

Item No. 25371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-benzeneacetamide
CAS Number
1838651-58-3
Molecular Formula
C22H18F3N5O
Formula Weight
425.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
220 nm
SMILES
O=C(NC1=NN(CC2=CC=C(C#N)C=N2)C=C1)CC3=CC=C(C4(CC4)C(F)(F)F)C=C3
InChi Code
InChI=1S/C22H18F3N5O/c23-22(24,25)21(8-9-21)17-4-1-15(2-5-17)11-20(31)28-19-7-10-30(29-19)14-18-6-3-16(12-26)13-27-18/h1-7,10,13H,8-9,11,14H2,(H,28,29,31)
InChi Key
LSYANGLAZUZYFX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $209

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    10 mg

    $290

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    25 mg

    $523

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    Product Description

    ACT-709478 is an inhibitor of T-type voltage-gated calcium channel 3.1 (Cav3.1), Cav3.2, and Cav3.3 (IC50s = 6.4, 18, and 7.5 nM, respectively).1 It is selective for T-type calcium channels over the L-type calcium channel Cav1.2 (IC50 = 2,410 nM). ACT-701478 (10 mg/kg) reduces the cumulative duration of absence-like seizures in rats. It also reduces the severity of seizures in a rat model of audiogenic seizures when administered at a dose of 100 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bezençon, O., Heidmann, B., Siegrist, R., et al. Discovery of a potent, selective T-type calcium channel blocker as a drug candidate for the treatment of generalized epilepsies. J. Med. Chem. 60(23), 9769-9789 (2017).